Skip to main content
. Author manuscript; available in PMC: 2013 Jul 12.
Published in final edited form as: J Chem Theory Comput. 2012 Apr 13;8(6):2115–2126. doi: 10.1021/ct300008d

Figure 4. Kullback-Leibler Divergences highlight most regions showing NMR chemical shift perturbations in IL-2.

Figure 4

Kullback-Leibler Divergences (blue) and NMR chemical shift perturbations over 5ppm (red) are shown for each IL-2 residue for binding of the micromolar IL-2Rα-competitive inhibitor. Though quantitatively there is no significant residue-by-residue correlation between the magnitudes of these different measures of perturbation to the protein, we note that the two signals often highlight similar regions.