. Author manuscript; available in PMC: 2013 Nov 26.

Published in final edited form as: J Med Chem. 2012 Nov 1;55(22):9541–9548. doi: 10.1021/jm300805x

Table 1.

Inhibition of NO synthesis by 20, 22, 23 and 26: IC₅₀ values (RM)

	iNOS	nNOS	eNOS	eNOS/iNOS	eNOS/nNOS
20	4.6 ± 0.33	34.6 ± 9.9	39.2 ± 9.2	8.5	1.1
22	1.8 ± 0.18	19.9 ± 7.6	9.1 ± 3.8	5.1	0.46
23	2.6 ± 0.18	13.7 ± 3.3	22.6 ± 3.6	8.7	1.6
26	4.7 ± 0.70	13.8 ± 2.1	38.2 ± 10.6	8.1	2.8

The reported IC₅₀ values are +/− SE; selectivity ratios of eNOS to the other isoforms are also reported.