Table 4.
GLCE SNPs and adjusted plasma triglyceride (mg/dl) levels in the 1990–1995 cohort
| Males | Females | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNPs | AA | AB | BB | p | Permuted p | AA | AB | BB | p | Permuted p | |
| |
|
||||||||||
| rs16952868 | 135 ± 81 (504) | 143 ± 92 (752) | 146 ± 95 (285) | 0.037 | 0.098 | 105 ± 62 (337) | 115 ± 83 (502) | 113 ± 78 (219) | NS | NS | |
| rs11631403 | 136 ± 83 (689) | 144 ± 90 (684) | 151 ± 109 (168) | 0.027 | 0.092 | 106 ± 61 (451) | 114 ± 85 (467) | 119 ± 84 (143) | 0.087 | NS | |
| rs17360351 | 139 ± 86 (1177) | 148 ± 94 (336) | 159 ± 137 (28) | 0.061 | NS | 109 ± 69 (792) | 118 ± 94 (251) | 120 ± 86 (17) | NS | NS | |
| rs3865014 | 137 ± 82 (824) | 144 ± 96 (609) | 153 ± 93 (105) | 0.037 | NS | 109 ± 75 (562) | 112 ± 72 (415) | 122 ± 96 (85) | NS | NS | |
| rs6545 | 138 ± 83 (626) | 142 ± 93 (689) | 148 ± 92 (214) | NS | NS | 110 ± 79 (440) | 108 ± 61 (468) | 122 ± 104 (147) | NS | NS | |
| GLCE | APOE | AA | AB | BB | p | Permuted p | AA | AB | BB | p | Permuted p |
|---|---|---|---|---|---|---|---|---|---|---|---|
| |
|
||||||||||
| rs16952868 | 3/3 + 3/4 | 136 ± 79 (432) | 140 ± 86 (645) | 143 ± 96 (243) | NS | NS | 103 ± 67 (281) | 107 ± 85 (425) | 109 ± 80 (183) | NS | NS |
| 2/3 | 130 ± 82 (66) | 153 ± 99 (75) | 154 ± 85 (40) | 0.021 | 0.042 | 92 ± 42 (44) | 111 ± 80 (66) | 123 ± 87 (28) | 0.027 | 0.074 | |
| rs11631403 | 3/3 + 3/4 | 136 ± 82 (588) | 139 ± 85 (583) | 144 ± 100 (146) | NS | NS | 103 ± 62 (380) | 107 ± 86 (393) | 111 ± 87 (121) | NS | NS |
| 2/3 | 136 ± 88 (80) | 150 ± 105 (77) | 152 ± 97 (27) | 0.044 | NS | 93 ± 45 (54) | 113 ± 81 (60) | 126 ± 94 (20) | 0.016 | 0.048 | |
| rs17360351 | 3/3 + 3/4 | 138 ± 87 (1004) | 145 ± 95 (288) | 146 ± 109 (26) | NS | NS | 104 ± 72 (665) | 111 ± 89 (212) | 114 ± 92 (15) | NS | NS |
| 2/3 | 143 ± 101 (134) | 145 ± 112 (46) | 149 ± 87 (3) | NS | NS | 106 ± 55 (99) | 118 ± 102 (34) | 133 ± 21 (2) | NS | NS | |
| rs3865014 | 3/3 + 3/4 | 137 ± 82 (706) | 139 ± 95 (520) | 145 ± 96 (92) | NS | NS | 106 ± 75 (470) | 105 ± 74 (348) | 117 ± 103 (71) | NS | NS |
| 2/3 | 134 ± 99 (91) | 151 ± 89 (72) | 163 ± 64 (18) | 0.021 | 0.043 | 95 ± 67 (71) | 120 ± 81 (57) | 122 ± 64 (11) | 0.014 | 0.046 | |
| rs6545 | 3/3 + 3/4 | 137 ± 83 (534) | 139 ± 91 (591) | 142 ± 97 (181) | NS | NS | 102 ± 80 (368) | 111 ± 67 (395) | 112 ± 99 (125) | NS | NS |
| 2/3 | 138 ± 98 (75) | 144 ± 96 (78) | 150 ± 77 (30) | 0.073 | NS | 102 ± 71 (59) | 107 ± 50 (62) | 125 ± 95 (18) | 0.043 | NS | |
All means ± SD were calculated by analysis of covariance using general linear models and were adjusted for age, body mass index, smoking, and alcohol consumption. Total number of subjects: 1549 males, 1063 females.
Number of subjects for each group is shown in parentheses. p values were calculated using an additive genotypic model in PLINK. Permutation Permuted???? p values were calculated from 50,000 random iterations in PLINK.
A, common allele; B, rare allele. NS, not significant (p ≥ 0.1). Significant (<0.05) results are shown in bold.