Table 5.
GLCE SNPs and adjusted plasma HDL-C (mg/dl) levels in the 1990–1995 cohort
| Males | Females | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNPs | AA | AB | BB | p | Permuted p | AA | AB | BB | p | Permuted p | |
| |
|
||||||||||
| rs16952868 | 36.4 ± 7.9 (504) | 35.4 ± 7.3 (752) | 35.3 ± 7.5 (285) | 0.029 | 0.091 | 41.1 ± 8.8 (337) | 41.4 ± 9.6 (502) | 40.9 ± 9.4 (219) | NS | NS | |
| rs11631403 | 36.1 ± 7.8 (689) | 35.5 ± 7.4 (684) | 35.0 ± 6.8 (168) | 0.046 | NS | 41.0 ± 8.8 (451) | 41.7 ± 9.6 (467) | 40.1 ± 9.8 (143) | NS | NS | |
| rs17360351 | 35.9 ± 7.6 (1177) | 35.4 ± 7.4 (336) | 35.0 ± 6.1 (28) | 0.300 | NS | 41.3 ± 9.1 (792) | 41.0 ± 10.1 (251) | 39.0 ± 7.5 (17) | NS | NS | |
| rs3865014 | 36.1 ± 7.9 (824) | 35.5 ± 7.2 (609) | 34.5 ± 6.7 (105) | 0.038 | 0.098 | 40.9 ± 8.6 (562) | 41.8 ± 10.1 (415) | 39.1 ± 9.7 (85) | NS | NS | |
| rs6545 | 36.1 ± 7.8 (626) | 35.6 ± 7.4 (689) | 35.2 ± 7.3 (214) | 0.092 | NS | 40.9 ± 8.6 (440) | 41.8 ± 9.9 (468) | 40.2 ± 9.6 (147) | NS | NS | |
| GLCE | APOE | AA | AB | BB | p | Permuted p | AA | AB | BB | p | Permuted p |
|---|---|---|---|---|---|---|---|---|---|---|---|
| |
|
||||||||||
| rs16952868 | 3/3 + 3/4 | 36.6 ± 7.9 (432) | 36 ± 7.4 (645) | 35.8 ± 7.4 (243) | NS | NS | 41.3 ± 8.9 (281) | 42.1 ± 9.6 (425) | 41.4 ± 9.5 (183) | NS | NS |
| 2/3 | 37.7 ± 9.6 (66) | 36.1 ± 6.8 (75) | 34.7 ± 6.7 (40) | 0.015 | 0.043 | 43.9 ± 9.5 (44) | 41.6 ± 9.1 (66) | 40.8 ± 8.9 (28) | NS | NS | |
| rs11631403 | 3/3 + 3/4 | 36.4 ± 8.0 (588) | 35.9 ± 7.4 (583) | 35.5 ± 6.8 (146) | NS | NS | 41.3 ± 9.0 (380) | 42.5 ± 9.7 (393) | 41.2 ± 9.8 (121) | NS | NS |
| 2/3 | 38 ± 9.0 (80) | 36.1 ± 7.1 (77) | 35.7 ± 6.9 (27) | 0.075 | NS | 42.9 ± 8.8 (54) | 42.2 ± 9.5 (60) | 40 ± 9.1 (20) | NS | NS | |
| rs17360351 | 3/3 + 3/4 | 36.2 ± 8.0 (1005) | 35.8 ± 7.5 (288) | 35.1 ± 7.1 (26) | NS | NS | 41.7 ± 9.1 (665) | 42.2 ± 10.1 (212) | 40.5 ± 6.8 (15) | NS | NS |
| 2/3 | 36.9 ± 8.3 (134) | 35.9 ± 7.8 (46) | 36.8 ± 9.1 (3) | NS | NS | 42.7 ± 9.4 (99) | 41.6 ± 8.3 (34) | 39.1 ± 16.3 (2) | NS | NS | |
| rs3865014 | 3/3 + 3/4 | 36.4 ± 8.1 (706) | 35.8 ± 7.4 (520) | 35.1 ± 7.4 (92) | NS | NS | 41.3 ± 8.9 (470) | 42.5 ± 10.1 (348) | 40.6 ± 9.7 (71) | NS | NS |
| 2/3 | 37.5 ± 8.9 (93) | 36.6 ± 7.3 (72) | 33.9 ± 6.5 (18) | 0.027 | 0.069 | 42.9 ± 8.4 (71) | 41.9 ± 9.9 (57) | 39.8 ± 9.2 (11) | 0.013 | 0.041 | |
| rs6545 | 3/3 + 3/4 | 36.5 ± 7.8 (534) | 35.8 ± 7.6 (591) | 35.7 ± 7.4 (181) | NS | NS | 41.4 ± 8.7 (368) | 42.1 ± 10.2 (395) | 41.6 ± 9.8 (125) | NS | NS |
| 2/3 | 37.3 ± 9.4 (75) | 36.9 ± 7.2 (78) | 34.6 ± 6.2 (30) | 0.085 | NS | 43.1 ± 9.1 (59) | 42.2 ± 9.6 (62) | 39.6 ± 8.6 (18) | NS | NS | |
All means ± SD were calculated by analysis of covariance using general linear models and were adjusted for age, body mass index, smoking, and alcohol consumption. Total number of subjects: 1549 males, 1063 females.
Number of subjects for each group is shown in parentheses. p values were calculated using an additive genotypic model in PLINK. Permutation Permuted??? p values were calculated from 50,000 random iterations in PLINK.
A, common allele; B, rare allele. NS, not significant (p ≥ 0.1). Significant (<0.05) results are shown in bold.