Table 6.
GLCE SNPs and adjusted plasma triglyceride (mg/dl) levels in the 2000–2003 cohort
| Males | Females | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| GLCE SNPs | AA | AB | BB | p | Permuted p | AA | AB | BB | p | Permuted p | |
| |
|
||||||||||
| rs16952868 | 148 ± 89 (153) | 157 ± 101 (228) | 160 ± 104 (87) | 0.043 | NS | 112 ± 66 (217) | 122 ± 88 (323) | 120 ± 83 (141) | NS | NS | |
| rs11631403 | 150 ± 91 (209) | 158 ± 99 (208) | 166 ± 120 (51) | 0.031 | 0.098 | 113 ± 65 (290) | 121 ± 90 (301) | 129 ± 89 (92) | 0.028 | 0.085 | |
| rs17360351 | 153 ± 95 (357) | 163 ± 103 (102) | 168 ± 151 (8) | 0.081 | NS | 116 ± 73 (510) | 125 ± 100 (162) | 128 ± 91 (11) | NS | NS | |
| rs3865014 | 151 ± 90 (250) | 158 ± 106 (185) | 168 ± 102 (32) | 0.041 | NS | 112 ± 80 (362) | 119 ± 77 (267) | 136 ± 102 (55) | 0.021 | 0.076 | |
| rs6545 | 152 ± 91 (190) | 156 ± 102 (209) | 163 ± 101 (65) | NS | NS | 117 ± 84 (283) | 115 ± 65 (301) | 130 ± 111 (95) | NS | NS | |
| GLCE | APOE | AA | AB | BB | p | Permuted p | AA | AB | BB | p | Permuted p |
|---|---|---|---|---|---|---|---|---|---|---|---|
| |
|
||||||||||
| rs16952868 | 3/3 + 3/4 | 149 ± 90 (131) | 152 ± 94 (195) | 155 ± 103 (75) | NS | NS | 108 ± 77 (188) | 115 ± 90 (281) | 112 ± 82 (123) | NS | NS |
| 2/3 | 141 ± 91 (19) | 162 ± 101 (22) | 166 ± 92 (12) | 0.017 | 0.045 | 100 ± 55 (23) | 119 ± 81 (33) | 120 ± 95 (15) | 0.077 | NS | |
| rs11631403 | 3/3 + 3/4 | 149 ± 93 (180) | 151 ± 95 (178) | 157 ± 104 (44) | NS | NS | 109 ± 72 (250) | 112 ± 92 (261) | 116 ± 89 (80) | NS | NS |
| 2/3 | 143 ± 92 (23) | 163 ± 98 (22) | 164 ± 99 (6) | 0.041 | NS | 98 ± 52 (28) | 115 ± 84 (34) | 139 ± 101 (10) | 0.018 | 0.048 | |
| rs17360351 | 3/3 + 3/4 | 151 ± 92 (306) | 157 ± 102 (87) | 159 ± 119 (7) | NS | NS | 110 ± 85 (442) | 117 ± 100 (142) | 120 ± 101 (10) | NS | NS |
| 2/3 | 155 ± 102 (38) | 159 ± 102 (12) | 164 (1) | NS | NS | 109 ± 61 (51) | 121 ± 88 (18) | 141 (1) | NS | NS | |
| rs3865014 | 3/3 + 3/4 | 149 ± 90 (210) | 155 ± 96 (164) | 158 ± 108 (30) | NS | NS | 111 ± 84 (311) | 114 ± 82 (231) | 123 ± 102 (50) | NS | NS |
| 2/3 | 147 ± 89 (27) | 166 ± 98 (22) | 178 ± 72 (4) | 0.021 | 0.047 | 99 ± 73 (37) | 126 ± 82 (27) | 128 ± 71 (7) | 0.023 | 0.048 | |
| rs6545 | 3/3 + 3/4 | 151 ± 95 (163) | 153 ± 102 (180) | 158 ± 103 (56) | NS | NS | 112 ± 85 (243) | 111 ± 73 (266) | 117 ± 101 (82) | NS | NS |
| 2/3 | 150 ± 94 (21) | 159 ± 101 (21) | 164 ± 71 (10) | 0.078 | NS | 107 ± 77 (28) | 115 ± 62 (30) | 126 ±101 (10) | 0.039 | NS | |
All means ± SD were calculated by analysis of covariance using general linear models and were adjusted for age, body mass index, smoking, and alcohol consumption. Total number of subjects: 474 males, 690 females.
Number of subjects for each group is shown in parentheses. p values were calculated using an additive genotypic model in PLINK. Permutation p values were calculated from 50,000 random iterations in PLINK.
A, common allele; B, rare allele. NS, not significant (p ≥ 0.1). Significant (<0.05) results are shown in bold.