Table 7.
GLCE SNPs and adjusted plasma HDL-C (mg/dl) levels in the 2000–2003 cohort
| Males | Females | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| GLCE SNPs | AA | AB | BB | p | Permuted p | AA | AB | BB | p | Permuted p | |
| |
|
||||||||||
| rs16952868 | 39.2 ± 8.6 (153) | 38.4 ± 7.9 (228) | 38.7 ± 8.1 (87) | NS | NS | 46.9 ± 9.9 (217) | 47.2 ± 11.0 (323) | 46.7 ± 10.7 (141) | NS | NS | |
| rs11631403 | 39.2 ± 8.5 (209) | 38.5 ± 8.0 (208) | 37.9 ± 7.4 (51) | 0.028 | 0.094 | 46.8 ± 9.8 (290) | 47.6 ± 11.0 (301) | 45.7 ± 11.2 (92) | 0.091 | NS | |
| rs17360351 | 38.8 ± 8.2 (357) | 38.4 ± 8.0 (102) | 38.3 ± 6.6 (8) | NS | NS | 47.1 ± 10.4 (510) | 46.8 ± 11.5 (162) | 44.5 ± 8.6 (11) | NS | NS | |
| rs3865014 | 39.1 ± 8.6 (250) | 38.5 ± 7.8 (185) | 37.4 ± 7.3 (32) | 0.039 | NS | 46.7 ± 9.8 (362) | 47.7 ± 11.5 (267) | 44.6 ± 11.1 (55) | NS | NS | |
| rs6545 | 39.1 ± 8.5 (190) | 38.6 ± 8.1 (209) | 38.2 ± 7.9 (65) | NS | NS | 46.7 ± 9.8 (283) | 47.7 ± 11.3 (301) | 45.9 ± 11.0 (95) | NS | NS | |
| GLCE | APOE | AA | AB | BB | p | Permuted p | AA | AB | BB | p | Permuted p |
|---|---|---|---|---|---|---|---|---|---|---|---|
| |
|
||||||||||
| rs16952868 | 3/3 + 3/4 | 39.4 ± 8.2 (131) | 38.9 ± 8.5 (195) | 38.5 ± 8.1 (75) | NS | NS | 46.8 ± 9.8 (188) | 48 ± 10.6 (281) | 48.1 ± 10.9 (123) | NS | NS |
| 2/3 | 40.9 ± 10.1 (19) | 39.3 ± 7.4 (22) | 39.5 ± 7.0 (12) | 0.085 | NS | 49.4 ± 10.8 (23) | 48.3 ± 10.2 (33) | 48.1 ± 10.4 (15) | NS | NS | |
| rs11631403 | 3/3 + 3/4 | 39.5 ± 8.5 (180) | 38.8 ± 8 (178) | 38.4 ± 7.9 (44) | NS | NS | 47.4 ± 9.8 (250) | 48.1 ± 10.9 (261) | 47 ± 11.2 (80) | NS | NS |
| 2/3 | 41.1 ± 9.4 (23) | 39.1 ± 7.5 (22) | 38.6 ± 7.1 (6) | 0.043 | NS | 49.5 ± 9.9 (28) | 48.4 ± 10.1 (34) | 46.2 ± 10.0 (10) | 0.021 | 0.048 | |
| rs17360351 | 3/3 + 3/4 | 39.2 ± 8.8 (306) | 38.7 ± 8.3 (87) | 38.2 ± 7.0 (7) | NS | NS | 46.9 ± 10.3 (442) | 47.7 ± 11.5 (142) | 45.5 ± 7.7 (10) | NS | NS |
| 2/3 | 39.6 ± 8.2 (38) | 38.9 ± 8.2 (12) | 39.3 (1) | NS | NS | 48.9 ± 10.9 (51) | 47.5 ± 9.4 (18) | 42.8 (1) | NS | NS | |
| rs3865014 | 3/3 + 3/4 | 39.4 ± 8.7 (210) | 38.7 ± 8 (164) | 38.1 ± 7.6 (30) | NS | NS | 47.5 ± 9.9 (311) | 48.1 ± 11.5 (231) | 46.6 ± 11 (50) | NS | NS |
| 2/3 | 40.5 ± 8.2 (27) | 39.8 ± 7.5 (22) | 36.8 ± 7.1 (4) | 0.017 | 0.044 | 49.6 ± 9.3 (37) | 47.8 ± 11.1 (27) | 46.1 ± 9.2 (7) | 0.036 | 0.091 | |
| rs6545 | 3/3 + 3/4 | 39.4 ± 8.8 (163) | 38.8 ± 8.3 (180) | 38.7 ± 8.2 (56) | NS | NS | 47 ± 9.8 (243) | 48.4 ± 11.3 (266) | 47.1 ± 10.9 (82) | NS | NS |
| 2/3 | 40.1 ± 9.1 (21) | 40.1 ± 7.7 (21) | 39.1 ± 6.7 (10) | NS | NS | 48.8 ± 10.6 (28) | 48.6 ± 10.8 (30) | 47.7 ± 9.8 (10) | NS | NS | |
All means ± SD were calculated by analysis of covariance using general linear models and were adjusted for age, body mass index, smoking, and alcohol consumption. Total number of subjects: 474 males, 690 females.
Number of subjects for each group is shown in parentheses. p values were calculated using an additive genotypic model in PLINK. Permutation p values were calculated from 50,000 random iterations in PLINK.
A, common allele; B, rare allele. NS, not significant (p ≥ 0.1). Significant (<0.05) results are shown in bold.