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. Author manuscript; available in PMC: 2013 Oct 12.
Published in final edited form as: Circ Res. 2012 Oct 12;111(9):1208–1221. doi: 10.1161/CIRCRESAHA.112.265819

Figure 3.

Figure 3

Regulation of mitophagy. Damaged mitochondria undergo DRP1-mediated fission prior to mitophagy. Reduced mitochondrial membrane potential leads to accumulation of PINK1 and subsequent recruitment of the E3 ubiquitin ligase Parkin to mitochondria. Parkin promotes ubiquitination of proteins in the mitochondrial membrane, which targets the damaged mitochondrion for removal by an autophagosome. The healthy mitochondrial fragment will undergo fusion mediated by MFN1/2 and OPA1. (Illustration Credit: Ben Smith).

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