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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Traffic. 2012 Nov 21;14(2):233–246. doi: 10.1111/tra.12024

Figure 8. Schematic model for interpreting the effect of Trs130 and other TRAPP II-specific subunits on autophagy.

Figure 8

Trs130 and other TRAPP II-specific subunits assemble together with TRAPP I to form the TRAPP II complex, which switches the small GTPases Ypt31 and Ypt32 from inactive form to active form, modulating intra-Golgi protein trafficking through and traffic from the Golgi to the plasma membrane (54), and autophagy (20). Mutation of TRS130 or related TRAPP II-specific subunits interferes with autophagy, including partial blocking of Atg8/Atg9 at the trans-Golgi in trs130ts. Transports of Atg8 and Atg9 from the trans-Golgi to the PAS are shown separately because the proteins have different characteristics. No evidence indicates that Atg8 and Atg9 move together from the trans-Golgi to the PAS. The GFP-Atg8 transport defect in TRAPP II-specific subunit mutants can be suppressed with Ypt31/32 but not Ypt1. We propose that Trs130/TRAPP II regulates autophagy at least partially through Ypt31/32 with regulation of autophagy proteins.