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. Author manuscript; available in PMC: 2014 Jan 15.
Published in final edited form as: J Immunol. 2012 Dec 12;190(2):723–736. doi: 10.4049/jimmunol.1201646

FIGURE 9.

FIGURE 9

CD86 Signaling Model. (Dotted arrows indicate proposed novel signaling events identified in the current study). CD86 engagement promotes the phosphorylation of IκBα via mechanisms regulated by Phb1/2 and the CD86 cytoplasmic domain allowing for the activation of NF-κB p50/p65. Concurrently, Phb1/2 alone promotes the CD86-induced PLCγ2 phosphorylation, allowing for subsequent PKCα/βII activation and phosphorylation of p65. NF- κB p50/p65 is now poised to initiate Oct-2 transcription, which ultimately regulates 3′IgH- enhancer activity to increase the rate of IgG1 transcription and the level of IgG1 produced by a B cell.