Groups of 20 wild-type (OR) or hop mutant flies were injected with SINV (A), VSV (B), FHV (C), DXV (D) or IIV6 (E), and survival was monitored. For VSV and SINV the Tris buffer control injection is also shown, since hop mutant flies showed decreased survival at 29°C after day 16 upon both buffer and virus injection. Kaplan-Meier analysis of the results of at least two independent experiments reveal a statistically significant difference in survival between wild-type and hop mutant flies only in the case of DXV (* p<0.05). ns: not significant.