Figure 3. KOs are associated with symptomatic atherosclerosis.

(a) Peptidoglycan KOs were enriched in patients and eight out of nine KOs correlated positively with white blood cell levels. (b) β-Oxidation KOs correlate with plasma triglyceride levels. (c) The glutamine synthetase—glutamine oxoglutarate aminotransferase system (K00265, K00266 and K01915) with high affinity for ammonium is enriched in patients. In all panels, red indicates enriched in patients (P), green indicates enriched in controls (C). *Adj. P<0.05, **adj. P<0.01 and ***adj. P<0.001. All samples were used for correlations with triglycerides, CRP (n=27, respectively) and white blood cell count (WBC; n=23). Only controls were used for low-density lipoprotein (LDL), high-density lipoprotein (HDL) and cholesterol correlations to avoid interactions with possible drug effects (n=15). Adj., adjusted.