Table 4. Adjusted hazard ratios of prognostic factor for primary outcome events.

	Overall patients		CKD (+)		CKD (−)
	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value
High-dose ARB	1.26 (0.86–1.86)	0.239	2.27 (1.22–4.23)	0.010	0.86 (0.51–1.44)	0.561
Male gender	1.79 (1.21–2.64)	0.004	1.66 (0.92–3.01)	0.092	1.96 (1.15–3.34)	0.013
Age⩾75 years	2.00 (1.35–2.97)	0.001	2.76 (1.40–5.43)	0.003	1.61 (0.96–2.71)	0.072
Previous CV disease	1.76 (1.02–3.04)	0.042	1.60 (0.65–3.95)	0.304	1.93 (0.96–3.85)	0.064
Previous diabetes	1.26 (0.81–1.94)	0.310	1.31 (0.68–2.52)	0.422	1.33 (0.73–2.43)	0.351

Abbreviations: ARB, angiotensin II receptor blocker; CKD, chronic kidney disease; CV, cardiovascular; HR, hazard ratio; 95% CI, 95% confidence interval.

CKD (+), patients with CKD at baseline; CKD (−), patients without CKD at baseline; high-dose ARB, allocation to high-dose ARB therapy.