Figure 1.

The TRPV4 topology and its domains. Transmembrane topology of the mouse TRPV4 (871 amino acids length). Indicated are the three ankyrin-binding repeats (ANK; as pentagon), the six trans-membrane regions (TM1-TM6), the Ca²⁺/F-actin- or microtubule-binding site (F-actin or microtubule), and the putative SGK1 phosphorylation site (S824) which is indicated by the arrow type (WT; Gene Bank #. BC127052). The putative cytoplasmic region of TRPV4 (718-871 amino acids) is also indicated by underlining.