Table 1.

Association of PAMP or DAMP sensors with autoimmune diseases.

Receptor	PAMP	DAMP	Autoimmune disease
TLR1/TLR2	Lipopeptide	Serum amyloid A protein	Atherosclerosis, rheumatoid arthritis, Crohn's disease
TLR4	LPS	Fatty acid	Obesity
		Hyaluronic acid	Rheumatoid arthritis, sarcoidosis, systemic sclerosis, pancreatic cancer
NLRP3	Uric acid	Uric acid	Hyperuricemia, gout
		ATP	Unknown
RIG-I, MDA5, TLR7/8	Virus RNA	Immunocomplex of snRNPs	SLE
TLR9	Bacterial DNA	Self-DNA-containing immune complexes, histone	SLE
RAGE	−/?	HMGB1	SLE
DAI, IFI16, AIM2, H2B, RNA pol III	Bacterial DNA, Virus DNA	Self-DNA?	SLE?