Table 2.

Association Between Framingham Risk Scores (per 10% Increase) and Subsequent Onset of Depressive Symptoms Before and After Age 65

Outcome	Predictora	Age at Onset <65				Age at Onset ≥65 (Later-Life)
		nb	n of Cases	Odds Ratio (95% CI)	p Value	nb	n of Cases	Odds Ratio (95% CI)	p Value
New-Onset GHQ Symptoms	CVD risk score	9445	1184	1.03 (.92, 1.15)	.59	1211	89	.97 (.79, 1.20)	.80
	CHD risk score	9445	1184	1.12 (.99, 1.25)	.06	1211	89	1.03 (.78, 1.36)	.83
	Stroke risk score	9445	1184	1.17 (.84, 1.64)	.35	1211	89	.83 (.54, 1.27)	.38
New-Onset CES-D Depressive Symptoms	CVD risk score	1916	59	1.42 (1.03, 1.96)	.04	870	39	1.09 (.80, 1.47)	.60
	CHD risk score	1916	59	1.44 (1.02, 2.03)	.04	870	39	1.00 (.63, 1.59)	.99
	Stroke risk score	1916	59	3.09 (1.48, 6.47)	.003	870	39	.83 (.43, 1.58)	.57
Starting Antidepressant Treatment	CVD risk score	14,045	283	1.19 (.99, 1.44)	.07	1657	32	1.16 (.85, 1.58)	.35
	CHD risk score	14,045	283	1.24 (1.02, 1.51)	.04	1657	32	1.08 (.68, 1.71)	.75
	Stroke risk score	14,045	283	1.06 (.57, 1.97)	.85	1657	32	.93 (.48, 1.79)	.83

CES-D, Center for Epidemiologic Studies Depression Scale; CHD, coronary heart disease; CI, confidence interval; CVD, cardiovascular disease; GHQ, General Health Questionnaire.

^aOdds ratio per each 10% increase in risk score adjusted for age and sex.

^bNumber of person observations.