Figure 4. Impaired long-term cued Fear Conditioning.

(A) In the cued fear conditioning training, neither group showed a significant freezing response to the chamber before the tone was presented (wt: n = 10 2.22 ± 1.00%; NR2A n = 10, 3.61 ± 2.00%). At the one hour recall session both the tg-NR2A and their wild-type littermates exhibited similar freezing responses to the tone (wt: n = 10, 68.69 ± 6.05%, NR2A: n = 10, 67.71 ± 4.60%). (B) In a separate cohort of animals at the 24 hour cued recall test the wild-type animals exhibited significantly more freezing than the tg-NR2A animals (wt: 68.33 ± 6.04%; NR2A 14.72 ± 6.1%; ** p = 2.96 × 10⁻⁶).