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. 2013 Jan 8;3:1036. doi: 10.1038/srep01036

Figure 6. Electrophysiology of hippocampal slices.

Figure 6

(A) There were no significant differences in the basal synaptic transmission as seen in the CA3-CA1 input-output curve. (B) The paired-pulse facilitation was unchanged between the Wt and the Tg animals indicating that the presynaptic function is unchanged. (C) A 100 Hz frequency for 1 s was able to produce similar LTP in Tg-NR2A animals and their wild-type littermates (wt: n = 6/3, NR2A: n = 8/6). (D) High frequency stimulation of 10 Hz for 10 s produced similar LTP in both the tg-NR2A animals and their wild-type littermates (wt: n = 7/4, NR2A: n = 5/3). (E) A 5 Hz stimulation for 180 s was also unable to produce LTD in the transgenic animals, also it was still able to produce LTD in the wild-type animals (wt: n = 4/3, NR2A: n = 5/4). (F) A 3 Hz stimulation for 300 s was unable to produce LTD in the transgenic animals, whereas the same stimulation was able to produce LTD in wild-type animals (wt: n = 7/3, NR2A: n = 5/3). (G) Low frequency stimulation (1 Hz for 900 s) induced similar LTD in both the wild-type and tg-NR2A animals (wt: n = 7/5, NR2A: n = 6/4). (H) There was no change seen in the depotentiation of the transgenic NR2A hippocampal slices.