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. 2013 Jan 8;3:1035. doi: 10.1038/srep01035

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(A) Effects of ARN080 (, n = 3) and ARN398 (, n = 3) on rat recombinant AC activity.(B) Effects of a 3-h incubation with ARN080 (3 µM, dotted bars), ARN398 (3 µM, closed bars) or vehicle (open bars) on ceramide levels in SW403 cells. (C−D) Effects of single () or multiple () exposure to ARN080 or ARN398 on SW403 cell viability. Isobolographic analyses of data obtained after multiple exposure of SW403 cells to (E) ARN080, 5-FU, or a combination of the two; (F) ARN398, 5-FU, or a combination of the two; (G) ARN080, taxol, or a combination of the two; (H) ARN398, taxol, or a combination of the two. T_h, IC₅₀ values expected if the effects were additive; E_x, experimental values actually obtained. Results are expressed as mean ± s.e.m. (n = 3), with each experiment performed twice. *p<0.05, **p<0.01, vs vehicle, one-way ANOVA followed by Tukey's test.

Inline graphic — (A) Effects of ARN080 (, n = 3) and ARN398 (, n = 3) on rat recombinant AC activity.(B) Effects of a 3-h incubation with ARN080 (3 µM, dotted bars), ARN398 (3 µM, closed bars) or vehicle (open bars) on ceramide levels in SW403 cells. (C−D) Effects of single () or multiple () exposure to ARN080 or ARN398 on SW403 cell viability. Isobolographic analyses of data obtained after multiple exposure of SW403 cells to (E) ARN080, 5-FU, or a combination of the two; (F) ARN398, 5-FU, or a combination of the two; (G) ARN080, taxol, or a combination of the two; (H) ARN398, taxol, or a combination of the two. T_h, IC₅₀ values expected if the effects were additive; E_x, experimental values actually obtained. Results are expressed as mean ± s.e.m. (n = 3), with each experiment performed twice. *p<0.05, **p<0.01, vs vehicle, one-way ANOVA followed by Tukey's test.