Table 1.
Frequency Distributions of BRAF Single-Nucleotide Polymorphisms' Genotypes in Cases and Controls and the Associations with Papillary Thyroid Cancer Risk Stratified by Age
| |
Age <45 years |
Age ≥45 years |
||||
|---|---|---|---|---|---|---|
| Variants | Cases, n (%) | Controls, n (%) | OR [CI]a | Cases, n (%) | Controls, n (%) | OR [CI]a |
| rs1042179: A>G | ||||||
| AA | 132 (71.4) | 185 (72.5) | 1.00 | 127 (69.8) | 216 (70.4) | 1.00 |
| AG | 48 (25.9) | 60 (23.5) | 1.24 [0.78–1.99] | 50 (27.5) | 86 (28.0) | 0.95 [0.62–1.46] |
| GG | 5 (2.7) | 10 (3.9) | 0.65 [0.21–2.05] | 5 (2.7) | 5 (1.6) | 1.90 [0.51–7.13] |
| GG+AG | 53 (28.6) | 70 (27.5) | 1.15 [0.74–1.80] | 55 (30.2) | 91 (29.6) | 1.00 [0.66–1.51] |
| rs11762469: A>T | ||||||
| AA | 121 (65.1) | 173 (67.8) | 1.00 | 127 (69.8) | 218 (70.8) | 1.00 |
| AT | 61 (32.8) | 77 (30.2) | 1.09 [0.71–1.68] | 50 (27.5) | 81 (26.3) | 1.04 [0.68–1.60] |
| TT | 4 (2.2) | 5 (2.0) | 1.08 [0.28–4.23] | 5 (2.7) | 9 (2.9) | 1.13 [0.35–3.68] |
| AT+TT | 65 (34.9) | 82 (32.2) | 1.09 [0.72–1.66] | 55 (30.2) | 90 (29.2) | 1.05 [0.69–1.59] |
| rs17161747: G>C | ||||||
| GG | 128 (68.8) | 168 (66.1) | 1.00 | 116 (63.7) | 205 (66.8) | 1.00 |
| GC | 50 (26.9) | 77 (30.3) | 0.80 [0.51–1.25] | 61 (33.5) | 88 (28.7) | 1.17 [0.77–1.77] |
| CC | 8 (4.3) | 9 (3.5) | 1.06 [0.38–2.95] | 5 (2.7) | 14 (4.6) | 0.61 [0.21–1.78] |
| GC+CC | 58 (31.2) | 86 (33.9) | 0.83 [0.54–1.26] | 66 (36.3) | 102 (32.2) | 1.09 [0.73–1.63] |
| rs3748093: T>A | ||||||
| TT | 104 (55.9) | 167 (66.8) | 1.00 | 115 (63.5) | 175 (58.3) | 1.00 |
| AT | 76 (40.9) | 70 (28.0) | 1.75 [1.14–2.69]b | 52 (28.7) | 113 (37.7) | 0.76 [0.50–1.15] |
| AA | 6 (3.2) | 13 (5.2) | 1.11 [0.37–3.33] | 14 (7.7) | 12 (4.0) | 2.33 [0.97–5.56] |
| AT+AA | 82 (44.1) | 83 (33.2) | 1.68 [1.11–2.54]b | 66 (36.5) | 125 (41.7) | 0.88 [0.60–1.31] |
a
ORs are adjusted for sex, cancer familial history, alcohol drinking, and smoking.
b
Boldface indicates statistical significance (p<0.05).
CI, 95% confidence interval; OR, odds ratio.