Table 3.
Frequency Distributions of BRAF Single-Nucleotide Polymorphisms' Genotypes in Cases and Controls and the Associations with Papillary Thyroid Cancer Risk Stratified by Cancer Familial History
| |
No |
Yes |
||||
|---|---|---|---|---|---|---|
| Variants | Cases, n (%) | Controls, n (%) | OR [CI]a | Cases, n (%) | Controls, n (%) | OR [CI]a |
| rs1042179: A>G | ||||||
| AA | 231 (69.6) | 358 (71.5) | 1.00 | 28 (80.0) | 43 (70.5) | 1.00 |
| AG | 91 (27.4) | 130 (25.9) | 1.11 [0.80–1.55] | 7 (20.0) | 16 (26.2) | 0.72 [0.25–2.08] |
| GG | 10 (2.8) | 13 (2.6) | 1.19 [0.49–2.90] | 0 (0) | 2 (3.3) | — |
| GG+AG | 101 (30.4) | 143 (28.5) | 1.12 [0.81–1.54] | 7 (20.0) | 18 (29.5) | 0.59 [0.21–1.67] |
| rs11762469: A>T | ||||||
| AA | 226 (67.9) | 351 (69.9) | 1.00 | 22 (62.9) | 40 (65.6) | 1.00 |
| AT | 100 (30.0) | 139 (27.7) | 1.10 [0.80–1.52] | 11 (31.4) | 19 (31.3) | 0.80 [0.31–2.07] |
| TT | 7 (2.1) | 12 (2.4) | 0.97 [0.36–2.62] | 2 (5.7) | 2 (3.3) | 2.41 [0.26–22.60] |
| AT+TT | 107 (32.2) | 151 (30.1) | 1.09 [0.80–1.50] | 13 (37.1) | 21 (34.4) | 0.91 [0.37–2.25] |
| rs17161747: G>C | ||||||
| GG | 229 (68.8) | 332 (66.3) | 1.00 | 15 (42.9) | 41 (68.3) | 1.00 |
| GC | 93 (27.9) | 152 (30.3) | 0.83 [0.60–1.14] | 18 (51.4) | 13 (21.7) | 4.74 [1.71–13.18]b |
| CC | 11 (3.3) | 17 (3.4) | 0.87 [0.39–1.94] | 2 (5.7) | 6 (10.0) | 0.84 [0.15–4.84] |
| GC+CC | 104 (3.2) | 169 (33.7) | 0.83 [0.61–1.14] | 20 (57.1) | 19 (31.7) | 3.24 [1.29–8.12]b |
| rs3748093: T>A | ||||||
| TT | 196 (59.0) | 303 (61.6) | 1.00 | 23 (65.7) | 39 (67.2) | 1.00 |
| AT | 116 (34.9) | 166 (33.7) | 1.13 [0.83–1.55] | 12 (34.3) | 17 (29.3) | 1.32 [0.51–3.40] |
| AA | 20 (6.0) | 23 (4.7) | 1.98 [0.99–3.99] | 0 (0.0) | 2 (3.4) | — |
| AT+AA | 136 (41.0) | 189 (38.4) | 1.21 [0.90–1.64] | 12 (34.3) | 19 (32.8) | 1.19 [0.47–3.04] |
a
ORs are adjusted for age, sex, drinking alcohol, and smoking.
b
Boldface indicates statistical significance (p<0.05).