Table 1.

Pharmacokinetics of Palifermin after Administration of the First (Day −11/−9) and Last (Day +3) Doses

Day	Number	Dosage, μg/kg/day	Clearance, mL/hour/kg, Mean ± SD	AUC, ng/hour/mL, Mean ± SD	Half-Life, Hours, Mean ± SD
−11/−9	12	40–90	1885 ± 497	40.5 ± 17.0	4.7 ± 0.7
	3	40	2268 ± 285	17.9 ± 2.3	4.1 ± 0.6
	3	60	1412 ± 554	46.7 ± 15.6	5.4 ± 0.8
	6	90	1930 ± 403	48.8 ± 11.2	4.7 ± 0.5
+3	12	40–90	1901 ± 513	40.7 ± 18.1	4.5 ± 0.5
	3	40	2243 ± 194	18.0 ± 1.7	4.1 ± 0.2
	3	60	1541 ± 656	43.5 ± 15.1	4.6 ± 0.5
	6	90	1911 ± 493	50.7 ± 14.0	4.7 ± 0.5