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. Author manuscript; available in PMC: 2013 Jan 8.
Published in final edited form as: Mol Cell Neurosci. 2011 May 24;47(4):293–305. doi: 10.1016/j.mcn.2011.05.008

Fig. 5. Df(16)A+/− mice do not display deficits in hippocampus-dependent reference memory in the MWM.

Fig. 5

(A) Experimental design for the habituation, visible platform training, hidden platform training, and probe trials of the MWM task. Habituation and visible platform training were for 2 days each, followed by 5 days of hidden platform training. Probe trials were conducted 1 hr and 24 hrs after the last training session. n = 12 mice per genotype. (B) Percent time spent in each quadrant during the probe trials. For both the 1 hr (left) and 24 hr (right) probe trials, Df(16)A+/− and wild-type mice exhibited a preference for the target quadrant (main effect of quadrant: p < 0.0001), with the two genotypes showing equal spatial preferences for the target quadrant (effect of genotype: p = 0.9032, comparisons of all quadrants to target quadrant (all p < 0.0001). (C) The total number of platform crossings, average distance from the platform, and total distance traveled during the 1 hr (top) and 24 hr (bottom) probe trials did not differ between genotypes (all p > 0.05)