Table 3.
Solubility of AH in different chemical enhancers and release rate of formulations through dialysis membrane.
| Formulation code | Solubilitya (mg/mL) | ERsol b | Release rate (μg/cm2/hr1/2) |
|---|---|---|---|
| Control | 23.34 ± 1.07 | 1 | 143.41 ± 0.10 |
| CA1 | 26.42 ± 1.05 | 1.13 | 223.37 ± 0.21 |
| CA2 | 29.34 ± 1.12 | 1.25 | 230.99 ± 0.05 |
| CA3 | 42.92 ± 0.65 | 1.83 | 58.95 ± 0.39 |
| CA4 | 27.65 ± 1.02 | 1.18 | 20.81 ± 0.28 |
| CA5 | 25.44 ± 1.08 | 1.08 | 194.75 ± 0.21 |
| CA6 | 33.53 ± 1.10 | 1.43 | 241.47 ± 0.08 |
| CA7 | 30.86 ± 1.43 | 1.32 | 205.35 ± 0.43 |
| CA8 | 35.32 ± 1.02 | 1.51 | 219.79 ± 0.25 |
| CA9 | 20.92 ± 1.12 | 0.89 | 396.36 ± 0.53 |
| CA10 | 28.67 ± 1.05 | 1.22 | 254.44 ± 0.18 |
| CA11 | 38.27 ± 1.03 | 1.63 | 197.61 ± 0.37 |
| CA12 | 42.60 ± 1.15 | 1.82 | 214.94 ± 0.25 |
| CA13 | 35.88 ± 0.87 | 1.53 | 324.07 ± 0.52 |
| CA14 | 26.90 ± 0.93 | 1.15 | 221.29 ± 0.32 |
| CA15 | 32.74 ± 1.15 | 1.40 | 219.26 ± 0.24 |
| CA16 | 40.61 ± 1.32 | 1.73 | 224.50 ± 0.29 |
aSolubility is the solubility of AH in the hydrogel solvent mixture at 25°C. bERsol is enhancement ratio of AH solubility over control solubility. Values represent mean ± S.D (n = 3).