Table 4.
Permeation parameters of AH formulations.
| Formulation code |
Q 24 (μg/cm2) | Flux (μg/cm2/hr) | Permeability coefficient (×10−03) (cm/hr) |
Lag time (hr) | Skin content (μg/gm) | ER |
|---|---|---|---|---|---|---|
| Control | 182.84 ± 7.81 | 7.59 ± 0.27 | 1.51 ± 0.05 | 2.96 ± 0.35 | 1246.79 ± 10.63 | 1 |
| CA1 | 274.17 ± 6.17 | 11.91 ± 0.16 | 2.38 ± 0.03 | 1.06 ± 0.15 | 981.20 ± 05.65 | 1.51 |
| CA2 | 365.05 ± 4.78 | 16.16 ± 0.22 | 3.23 ± 0.04 | 2.26 ± 0.15 | 754.61 ± 16.47 | 2.05 |
| CA3 | 307.43 ± 6.40 | 14.24 ± 0.19 | 2.84 ± 0.03 | 2.70 ± 0.20 | 342.33 ± 05.30 | 1.80 |
| CA4 | 257.73 ± 6.02 | 12.56 ± 0.19 | 2.51 ± 0.03 | 2.33 ± 0.15 | 1032.36 ± 07.93 | 1.59 |
| CA5 | 267.59 ± 6.66 | 12.51 ± 0.19 | 2.50 ± 0.03 | 1.76 ± 0.15 | 1133.28 ± 11.33 | 1.58 |
| CA6 | 589.89 ± 5.05 | 25.34 ± 0.09 | 5.06 ± 0.01 | 0.76 ± 0.15 | 955.63 ± 09.41 | 3.21 |
| CA7 | 383.55 ± 7.03 | 17.08 ± 0.21 | 3.41 ± 0.04 | 0.80 ± 0.10 | 676.34 ± 09.68 | 2.16 |
| CA8 | 566.02 ± 4.71 | 25.88 ± 0.08 | 5.17 ± 0.01 | 1.10 ± 0.20 | 567.82 ± 11.96 | 3.28 |
| CA9 | 518.65 ± 6.69 | 22.39 ± 0.20 | 4.47 ± 0.04 | 1.23 ± 0.15 | 713.82 ± 12.33 | 2.84 |
| CA10 | 702.74 ± 7.49 | 30.38 ± 0.18 | 6.07 ± 0.03 | 0.30 ± 0.20 | 592.20 ± 08.54 | 3.85 |
| CA11 | 507.26 ± 6.73 | 22.67 ± 0.18 | 4.53 ± 0.03 | 0.46 ± 0.15 | 651.33 ± 09.00 | 2.87 |
| CA12 | 702.28 ± 6.97 | 31.08 ± 0.21 | 6.21 ± 0.04 | 0.13 ± 0.05 | 355.93 ± 08.60 | 3.94 |
| CA13 | 351.39 ± 6.95 | 14.87 ± 0.14 | 2.97 ± 0.02 | 0.50 ± 0.10 | 877.00 ± 08.28 | 1.88 |
| CA14 | 303.85 ± 6.08 | 12.99 ± 0.15 | 2.59 ± 0.03 | 0.83 ± 0.15 | 561.93 ± 09.26 | 1.64 |
| CA15 | 314.25 ± 4.80 | 14.79 ± 0.09 | 2.95 ± 0.01 | 1.33 ± 0.15 | 875.97 ± 08.61 | 1.87 |
| CA16 | 490.75 ± 6.04 | 21.38 ± 0.08 | 4.27 ± 0.01 | 0.43 ± 0.15 | 687.58 ± 08.30 | 2.71 |
Q 24 is the cumulative amount permeated in 24 hrs; ER is an enhancement ratio of the flux of chemical enhancers over control. Values represent mean ± S.D (n = 3).