Table 2.
Transplant-related characteristics of renal transplant recipients according to CMV serostatus >1 year after transplantation.
| CMV serostatus >1 year after transplantation | P | |||
|---|---|---|---|---|
| Negative | Seroconverted | Seropositive | ||
| n (%) | 174 (29) | 152 (25) | 280 (46) | |
| Donor demographics | ||||
| Age (years) | 35.9±15.4 | 34.8±14.9 | 38.7±15.6 | 0.02 |
| Male, n (%) | 98 (56) | 82 (54) | 148 (53) | 0.8 |
| Renal allograft function | ||||
| Serum creatinine concentration (ìmol/L) | 136 [112–162] | 129 [111–170] | 134 [114–166] | 0.8 |
| Creatinine clearance (mL/min) | 66.5±21.2 | 59.6±21.3 | 60.5±23.5 | 0.007 |
| Proteinuria (g/24hr) | 0.2 [0.0–0.4] | 0.2 [0.0–0.5] | 0.2 [0.0–0.5] | 0.7 |
| Prior dialysis duration (mo) | 25 [12–47] | 26 [15–29] | 29 [16–53] | 0.09 |
| Transplantation type, n (%) | ||||
| Postmortem donor | 137 (79) | 134 (88) | 232 (83) | 0.06 |
| Living donor | 33 (19) | 15 (10) | 35 (12) | |
| Combined transplantation | 4 (2) | 3 (2) | 13 (5) | |
| Number of previous transplants, n (%) | ||||
| 0 | 163 (94) | 134 (88) | 245 (88) | 0.01 |
| 1 or more | 11 (6) | 18 (12) | 35 (12) | |
| Acute rejection, n (%) | 77 (44) | 77 (51) | 118 (42) | 0.2 |
| Immunosuppressive era, n (%) | ||||
| from 1968 to January 1989 | 30 (17) | 65 (43) | 17 (6) | <0.0001 |
| from January 1989 to February 1993 | 19 (11) | 17 (11) | 54 (20) | |
| from March 1993 to May 1997 | 42 (24) | 32 (21) | 83 (29) | |
| from May 1997 to date | 83 (48) | 38 (25) | 126 (45) | |
| Immunosuppresion | ||||
| Prednisolone dose, (mg/day) | 10.0 [7.5–10.0] | 10.0 [7.5–10.0] | 10.0 [7.5–10.0] | 0.04 |
| Calcineurine inhibitor, n (%) | 140 (81) | 94 (62) | 241 (86) | P=0.04 |
| Cyclosporin, n (%) | 112 (65) | 81 (53) | 197 (70) | 0.5 |
| Trough–level (μg/L) | 114 [82–140] | 101 [75–128] | 108 [80–143] | 0.2 |
| Tacrolimus, n (%) | 28 (16) | 13 (9) | 44 (16) | 0.5 |
| Trough–level (μg/L) | 8 [6–11] | 10 [7–11] | 9 [6–10] | 0.7 |
| Proliferation inhibitor, n (%) | ||||
| Azathioprine or Mycophenolate mofetil | 133 (76) | 107 (70) | 208 (74) | 0.5 |
Values are presented as mean ±standard deviation, median (interquartile range) or percentages. P for trend was calculated with χ-square, Kruskal Wallis test and linear regression for dichotomous, ordinal and continuous variables, respectively. Skewed data were normalized by logarithmic transformation in all analyses.