Table 2.
Clinical and biochemical characteristics of the subjects according to KCNQ1 rs163184 genotypes.
| TT (n=20) | TG (n=39) | GG (n=28) | p | |
|---|---|---|---|---|
| Gender (males/females) | 11/9 | 20/19 | 11/17 | 0.491* |
| Age (years) | 63.7±2.2 | 61.8±1.6 | 63.8±1.9 | 0.683 |
| Diabetes duration (years) | 5.7±0.8 | 6.4±0.5 | 5.7±0.6 | 0.641 |
| Weight (kg) | 83.9±3.9 | 84.8±2.8 | 83.8±3.0 | 0.960 |
| BMI (kg/m2) | 29.8±0.8 | 30.9±0.6 | 30.3±0.7 | 0.513 |
| FPG (mmol/L) – baseline | 8.20±0.32 | 8.67±0.23 | 8.60±0.27 | 0.465 |
| FPG (mmol/L) – after treatment | 7.11±0.25 | 6.87±0.18 | 7.50±0.21 | 0.076 |
| ΔFPG (mmol/L) | 1.31±0.22 | 1.72±0.15** | 1.04±0.18 | 0.017 |
| HbA1c (%) – baseline | 7.84±0.20 | 8.07±0.14 | 7.96±0.17 | 0.640 |
| HbA1c (%) – after treatment | 6.90±0.13 | 6.96±0.10 | 7.06±0.11 | 0.632 |
| ΔHbA1c (%) | 1.04±0.11 | 1.05±0.08 | 0.92±0.09 | 0.523 |
| Total cholesterol (mmol/L) | 4.94±0.20 | 5.38±0.14 | 5.25±0.18 | 0.209 |
| LDL cholesterol (mmol/L) | 2.74±0.14 | 2.85±0.10 | 2.71±0.13 | 0.684 |
| HDL cholesterol (mmol/L) | 1.14±0.06 | 1.13±0.04 | 1.11±0.06 | 0.911 |
| Triglycerides (mmol/L) | 2.11±0.16 | 2.04±0.11 | 2.23±0.14 | 0.590 |
Data are expressed as mean ±SE.
*
p refers to χ2-test, otherwise p refers to ANOVA. ΔFPG and ΔHbA1c means were adjusted in general linear models for gender, age, BMI and baseline FPG or HbA1c values, respectively.
**
p=0.015 for comparison TG vs. GG (Bonferroni test). BMI – body mass index; FPG – fasting plasma glucose; LDL – low-density lipoprotein; HDL – high-density lipoprotein.