This figure shows that resistant rates of E. coli to various uroantiseptic drugs were the highest for ampicillin and TMP/SMX. During the period of observance E. coli’s resistance to TMP/SMX had significantly increasing trend, to cephalexin had significantly decreasing trend while to amoxicillin/clavulonic acid had 93% probability to have decreasing trend. Resistance rates of E. coli did not change significantly to ampicillin and to nitrofurantoin during the period of observance. Spearman’s correlation coefficient (ρ) and χ2 (p) were as follows: to ampicillin (ρ=−0.120; p=0.776), to TMP/SMX (ρ=0.762; p=0.028), to cephalexin (ρ=−0.786; p=0.021), amoxicillin/clavulonic acid (ρ=−0.66; p=0.075), and to nitrofurantoin (ρ=−0.192; p=0.648).