Table 2.
Maximum toxicity per patient (n=75) – 1293 chemotherapy applications and 226 cycles.
| Toxicity | NCI-CTC Grad [n (%)] | ||||
|---|---|---|---|---|---|
| Grade 0 | Grade 1 | Grade 2 | Grade 3 | Grade 4 | |
| Haematological | |||||
| Anaemia | 34 (45) | 14 (18) | 22 (29) | 5 (7) | – |
| Leucopenia | 44 (59) | 20 (27) | 10 (13) | 1 (1) | – |
| Thrombopenia | 71 (95) | 4 (5) | – | – | – |
| Nonhaematological | |||||
| Diarrhea | 17 (23) | 26 (35) | 19 (25) | 13 (17) | – |
| Nausea | 11 (15) | 46 (61) | 16 (21) | 2 (3) | – |
| Vomiting | 27 (36) | 33 (44) | 8 (11) | 7 (9) | – |
| Loss of appetite | 35 (46) | 28 (37) | 11 (15) | 1 (1) | – |
| Fatigue | 44 (59) | 28 (37) | 3 (4) | – | – |
| Hand-foot syndrome | 59 (79) | 15 (20) | 1 (1) | – | – |
| Mucositis | 61 (81) | 13 (17) | 1 (1) | – | – |
| Neurological failures | 70 (93) | 5 (7) | – | – | – |
| Thromboembolism | 65 (87) | 3 (4) | 4 (5) | 2 (3) | 1 (1) |
| Increase of creatinine | 57 (76) | 12 (16) | 5 (7) | 1 (1) | – |
| Infections | 52 (69) | 8 (11) | 6 (8) | 8 (11) | 1 (1) |
| Fever | 59 (79) | 5 (7) | 10 (13) | 1 (1) | – |
| Ascites | 53 (71) | 12 (16) | 8 (11) | 2 (3) | – |
| Oedema | 68 (91) | 3 (4) | 4 (5) | – | – |
| GI bleeding | 65 (87) | 5 (7) | 2 (3) | 2 (3) | 1 (1) |
| Obstipation | 61 (81) | 14 (19) | – | – | – |
| Dysphagia | 64 (85) | 7 (9) | 2 (3) | 1 (1) | 1 (1) |
| Alopecia | 63 (83) | 10 (13) | 2 (3) | – | – |
GI – Gastrointestinal.