Table 6.
Distribution of genotypes, frequency of alleles of the c.544G>A polymorphism of the heme oxygenase-2 gene and odds ratios (OR) with 95% confidence intervals (95% CI) in age-related macular degeneration and controls among smokers and non-smokers.
| Genotype/allele | Never-smokers | Ever-smokers | ||||
|---|---|---|---|---|---|---|
| Controls N=52 number (%) | Patients N=104 number (%) | OR1 (95% CI) | Controls N=32 number (%) | Patients N=65 number (%) | OR1 (95% CI) | |
| AA | 30 (0.58) | 59 (0.57) | 1.02 (0.45–2.12) | 16 (0.50) | 41 (0.63) | 1.41 (0.54–3.71) |
| AG | 20 (0.38) | 43 (0.41) | 1.10 (0.53–2.31) | 14 (0.44) | 19 (0.29) | 0.64 (0.23–1.74) |
| GG | 2 (0.04) | 2 (0.02) | 0.31 (0.03–2.94) | 2 (0.06) | 5 (0.08) | 1.28 (0.20–8.04) |
| A | 80 (0.77) | 161 (0.77) | 3.17 (0.34–29.54) | 46 (0.72) | 101 (0.78) | 0.78 (0.12–4.90) |
| G | 24 (0.23) | 47 (0.23) | 0.98 (0.47–2.03) | 18 (0.28) | 29 (0.22) | 0.71 (0.27–1.87) |
1
Adjusted for age, sex and family AMD history.