Figure 7.

IL-10 antibody abates the survival benefit of BMSC-CM-administered to rats undergoing lethal cisplatin AKI. At hour 0, cisplatin dissolved in physiological saline (0.75 mg/mL) was administered i.p. to male, SAS-SD rats at a lethal dose (7.5 mg/kg). At hours 3, 9, 24, 48, and 72, 1 mL of either physiological saline (n = 12), BMSC-conditioned medium (n = 14) or BMSC-conditioned medium containing 4 μg/mL neutralizing anti-rat IL-10 antibody (n = 10) were administered i.v. to the cisplatin AKI rats. They were monitored for survival for 30 days. *P < 0.05 for BMSC-CM compared to saline by Logrank test.