Table 4.
Current | C | N | M | K | G | |||||
---|---|---|---|---|---|---|---|---|---|---|
Control | cAF | Control | cAF | Control | cAF | Control | cAF | Control | cAF | |
INa | −440.15 | −427.77 | −317.39 | −328.65 | −347.84 | −370.27 | −332.62 | −375.75 | −564.11 | −1749.59 |
IbNa | −0.23 | −0.23 | −0.41 | −0.43 | −0.41 | −0.42 | −0.40 | −0.42 | −0.51 | −0.54 |
ICaL | −9.88 | −3.62 | −10.48 | −3.57 | −9.87 | −3.15 | −19.50 | −5.09 | −47.56 | −18.77 |
IbCa | −0.55 | −0.57 | −0.77 | −0.81 | −0.76 | −0.79 | −0.78 | −0.80 | −0.68 | −0.71 |
INCX,max | 1.33 | 1.48 | 2.81 | 3.61 | 2.91 | 3.66 | 0.69 | 0.91 | 0.16 | 0.70 |
INCX,min | −0.76 | −0.78 | −1.72 | −0.95 | −1.55 | −0.88 | −0.76 | −0.83 | −5.02 | −1.62 |
INKA | 0.54 | 0.54 | 0.89 | 0.90 | 0.86 | 0.86 | 0.89 | 0.92 | 1.64 | 1.67 |
IPMCA | 0.38 | 0.27 | 0.16 | 0.15 | 0.16 | 0.15 | 0.06 | 0.05 | 0.26 | 0.14 |
Ito | 23.31 | 10.69 | 19.59 | 9.28 | 23.00 | 10.67 | 24.16 | 10.61 | 30.39 | 25.82 |
IKur | 7.03 | 5.45 | 13.67 | 8.15 | 11.34 | 6.67 | 12.66 | 7.24 | 16.29 | 15.52 |
IKr | 0.55 | 0.50 | 0.07 | 0.10 | 0.08 | 0.12 | 0.09 | 0.13 | 0.07 | 0.53 |
IKs | 0.21 | 0.09 | 4.98 | 6.05 | 0.04 | 0.07 | 0.05 | 0.07 | 0.01 | 3.34E-3 |
IK1 | 1.17 | 2.46 | 1.24 | 2.60 | 1.29 | 2.69 | 1.29 | 2.71 | 1.33 | 15.91 |
The currents are normalized to the value of IK1 after 50 s clamped to a transmembrane voltage of −75 mV.
Model specific currents:
M model: IKACh = 6.09E-11 (6.30E-11); K model: If = 0.20 (0.33); and G model: IKp = 2.18E − 3 (1.17), ICl(Ca) = 0.80 (0.12), IbCl = 3.64 (5.92).