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. 2012 Dec 20;2012:639469. doi: 10.1155/2012/639469

Figure 3.

Figure 3

Effect of fisetin on HAT and HDAC activity as well as p300 and acetylated CBP/p300 levels in HG-treated THP-1 cells. Cells were harvested after 48 h of fisetin treatment and nuclear lysates were prepared. Samples were analyzed for determination of HAT (a) and HDAC activity (b). Results are shown as mean ± SD for 3 different experiments. †† P < 0.01 compared to NG; *P < 0.05; **P < 0.01 compared to HG. (c) After nuclear protein extraction, p300 and acetylated CBP/p300 levels were evaluated by western blot. The immunoblots shown here are representative of 3 independent experiments.