Front paw print area (A), hind paw print area (B), percent of diagonal support (C), and total duration of ambulatory movement on walkway (D) are presented. Ts65Dn mice showed significantly smaller paw print area, a higher percentage of diagonal support, and shorter duration of ambulatory movement compared to 2N controls (main effect of genotype). Results are presented as Mean + SEM, n(male and female 2N)=10 and n(male and female Ts65Dn)=11. Within group comparison between Ts65Dn mice and 2N mice was analyzed and only the significant differences are shown (*=p<0.05 and **=p<0.01).