Figure 1.
Electron photomicrographs of mouse extraocular muscle neuromuscular junction (NMJ) types. (A, B) Orbital singly innervated fibers (SIF) NMJs encircle individual myofibers, with long terminals (t) embedded in deep depressions of the myofiber surface. Terminals are capped by Schwann cells (S). Postjunctional folding is either absent or sparse (arrowheads), and postjunctional accumulations of myonuclei (mn) and mitochondria (m) is evident. Multiply innervated fibers (MIF) NMJs are small and do not lie in sarcolemmal depressions for both orbital (C, D) and global (E) fiber types. The range of variability in global SIF NMJs includes most junctions with few or no folds (F), but junctions with a high density of postjunctional folds (G) are found, primarily on the global pale SIF type. Reproduced, with permission from Khanna and Porter, IOVS, May 2003, Vol. 44, No. 5.