Table 1.
E-values* for viral MHC-I homologs
| MHC-I homolog | size (aa) | BLASTP† (sequence homology) | 3D-PSSM‡ (structural homology) | ||
|---|---|---|---|---|---|
|
| |||||
| E-value | MHC-I (sequence) | E-value | MHC-I (structure) | ||
| UL18§ | 368 | 4e−18 | human (CAL85437.2) | 6e−6 | human (ABA41587) |
| m144§ | 383 | 6e−9 | mouse (AAA39553) | 1e−4 | mouse (AAR11190 |
| UL142∥ | 306 | n.s. | not applicable | 0.15 | human (ABV71649) |
| m157∥ | 331 | n.s. | not applicable | 0.089 | mouse (AAR11192) |
| gp147 | 520 | 0.4 | tuatara (ABA42599) | 0.83 | human (AAA98727.1) |
| gp148 | 483 | 8e−8 | rhesus (BAG69572) | 2.3 | mouse (CAA26586.1) |
| gp149 | 627 | n.s. | not applicable | 0.49 | mouse (AAA53200.1) |
| cI-M (aa 133–339) | 207 | 0.049 | platypus (XP001511789) | 0.04 | human (ABY26532.1) |
*
E-values reflect the probability that sequence or structural similarity between two proteins is random. E-values < 1 indicate a significant probability that a similarity is non-random and this probability increases with decreasing E-value; n.s., no significant similarity
§
known MHC-I sequence homologs
∥
known MHC-I structural homologs