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. Author manuscript; available in PMC: 2013 Jan 8.
Published in final edited form as: Horm Mol Biol Clin Investig. 2012 Feb;9(2):143–163. doi: 10.1515/hmbci-2011-0004

Figure 6.

Figure 6

The diagrammatic representation of cellular estrogen receptor (ER) regulation in media with or without estradiol (E2). This diagram is based on the general responses to estrogen illustration by Western blotting in Figure 2 and presented in detail in [45]. Model I ER regulation (MCF-7, ZR-75, BT-474) has an upregulation of ER message and protein in an estrogen-depleted environment, but ER is downregulated at the mRNA and protein level in the presence of estrogen. Model II ER regulation (T47D) has upregulation of ER message and protein in an estrogen-containing environment but ER is not produced in an estrogen-depleted environment. Cells lose ER to become ER-negative.