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. 2012 Dec 5;32(49):17775–17787. doi: 10.1523/JNEUROSCI.3049-12.2012

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Copyright © 2012 the authors 0270-6474/12/3217775-13$15.00/0

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Figure 9. — Autophagosome-like vacuoles exist in hSYN^A53T mice, not hSYN^A53T/GFAP-Nrf2 double transgenic mice. A, Electron microscopic (EM) images of motor neurons in lumbar spinal cord from 8-month-old hSYN^A53T mice, hSYN^A53T/GFAP-Nrf2 mice, and littermate controls. B, Top and middle, autophagosome-like vacuoles in cell body and axon of neurons from hSYN^A53T mouse with symptoms. Scale bars: 5 μm. Higher magnification images of the square areas are shown on the right. Scale bars: 1 μm (top) and 500 nm (middle). Arrows denote the vacuoles. Bottom, A healthier looking neuron from hSYN^A53T mouse with vacuolated (arrows) and normal (arrowheads) lysosomes. Scale bars: 5 μm (left) and 1 μm (right). C, EM images for hSYN^A53T/GFAP-Nrf2 mouse. Higher magnification images of the square areas are shown on the right. Scale bars: 5 μm (left) and 1 μm (right).