Table 3.
Peripheral QCT skeletal measures by clinical cutoffs of serum 25(OH)D (ng/ml)
| Caucasians | African Descent | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Deficient (<20) N=70 Mean (SE) | Insufficient (20–<30) N=214 Mean (SE) | Sufficient (≥30) N=162 Mean (SE) | P for trend | Deficient (<20) N=22 Mean (SE) | Insufficient (20–<30) N=122 Mean (SE) | Sufficient (≥30) N=352 Mean (SE) | P for trend | P interaction race and serum 25 (OH)D | |
| Distal radius (33%) | |||||||||
| Cortical vBMD (mg/cm3) | 1149.3 (6.7) | 1151.6 (6.1) | 1158.3 (6.3) | 0.042 | 1200.7 (6.3) | 1199.6 (2.8) | 1203.9 (1.6) | 0.229 | 0.359 |
| Total BMC (mg/mm) | 125.7 (3.6) | 128.0 (3.3) | 132.4 (3.4)* | 0.007 | 149.4 (4.1) | 147.2 (1.8) | 144.5 (1.1) | 0.107 | 0.003 |
| Cortical thickness (mm) | 3.11 (0.10) | 3.19 (0.09) | 3.32 (0.09)* | 0.003 | 3.52 (0.09) | 3.52 (0.04) | 3.54 (0.02) | 0.670 | 0.054 |
| Total area (mm2) | 143.2 (4.1) | 143.4 (3.8) | 145.9 (3.9) | 0.291 | 161.6 (5.0) | 155.7 (2.2) | 150.5 (1.3) | 0.005 | 0.006 |
| SSIp (mm3) | 354.0 (14.4) | 363.3 (13.3) | 376.5 (13.7) | 0.028 | 436.4 (18.2) | 426.3 (8.1) | 412.1 (4.7) | 0.060 | 0.005 |
| SSIx (mm3) | 193.5 (7.9) | 200.0 (7.3) | 207.8 (7.5) | 0.012 | 243.2 (10.4) | 239.9 (4.6) | 230.4 (2.7) | 0.048 | 0.002 |
| Ultra distal radius (4%) | |||||||||
| Trabecular vBMD (mg/cm3) | 194.0 (9.0) | 182.5 (8.3) | 181.6 (8.5) | 0.118 | 187.5 (11.9) | 201.2 (5.3) | 204.9 (3.0) | 0.170 | 0.015 |
| Total BMC (mg/mm) | 126.1 (4.8) | 122.6 (4.5) | 127.9 (4.6) | 0.310 | 139.7 (5.4) | 142.1 (2.4) | 140.6 (1.4) | 0.792 | 0.480 |
| Cross-sectional area (mm2) | 361.9 (13.6) | 362.4 (12.6) | 371.8 (13.0) | 0.244 | 349.3 (13.0) | 354.3 (5.8) | 344.6 (3.3) | 0.217 | 0.109 |
| SSIp (mm3) | 493.8 (27.0) | 484.6 (25.0) | 516.6 (25.8) | 0.118 | 596.1 (30.2) | 589.3 (13.4) | 576.2 (7.7) | 0.327 | 0.079 |
| SSIx (mm3) | 267.9 (14.8) | 258.6 (13.7) | 275.1 (14.1) | 0.252 | 316.6 (16.6) | 320.9 (7.4) | 316.9 (4.3) | 0.754 | 0.328 |
| Distal tibia (33%) | |||||||||
| Cortical vBMD (mg/cm3) | 1122.0 (6.6) | 1124.6 (6.1) | 1129.8 (6.2) | 0.090 | 1173.3 (7.5) | 1166.4 (3.2) | 1168.6 (1.8) | 0.975 | 0.232 |
| Total BMC (mg/mm) | 378.4 (9.4) | 388.9 (8.7) | 396.4 (8.8)* | 0.012 | 403.9 (12.6) | 415.7 (5.4) | 413.4 (3.1) | 0.840 | 0.465 |
| Cortical thickness (mm) | 5.31 (0.14) | 5.33 (0.13) | 5.54 (0.13)** | 0.009 | 5.19 (0.18) | 5.37 (0.08) | 5.36 (0.04) | 0.595 | 0.314 |
| Cross-sectional area (mm2) | 461.8 (11.2) | 475.3 (10.3) | 474.4 (10.5) | 0.241 | 506.1 (17.7) | 515.9 (7.6) | 508.0 (4.3) | 0.559 | 0.525 |
| SSIp (mm3) | 2046.7 (71.7) | 2126.3 (66.3) | 2158.5 (67.3) | 0.053 | 2384.6 (107.8) | 2510.7 (46.3) | 2458.8 (26.3) | 0.800 | 0.500 |
| SSIx (mm3) | 1278.5 (46.3) | 1333.7 (42.8) | 1350.9 (43.5) | 0.060 | 1463.0 (73.4) | 1549.2 (31.5) | 1513.8 (17.9) | 0.783 | 0.382 |
| Ultra distal tibia (4%) | |||||||||
| Trabecular vBMD (mg/cm3) | 224.5 (7.8) | 222.3 (7.1) | 228.7 (7.2) | 0.282 | 224.0 (10.4) | 233.4 (4.5) | 226.3 (2.6) | 0.475 | 0.383 |
| Total BMC (mg/mm) | 359.1 (12.2) | 359.9 (11.2) | 369.3 (11.3) | 0.173 | 374.0 (14.0) | 380.5 (6.0) | 370.4 (3.4) | 0.277 | 0.215 |
| Cross-sectional area (mm2) | 1252.8 (34.7) | 1253.5 (31.9) | 1260.2 (32.3) | 0.731 | 1260.6 (40.3) | 1214.1 (17.2) | 1204.1 (9.9) | 0.225 | 0.298 |
| SSIp (mm3) | 2215.6(140.6) | 2273.6(129.3) | 2375.3(131.1) | 0.099 | 2536.4 (154.2) | 2606.1 (65.9) | 2526.7 (37.7) | 0.481 | 0.231 |
| SSIx (mm3) | 1189.7 (77.0) | 1193.3 (70.9) | 1242.0 (71.8) | 0.267 | 1264.3 (82.1) | 1322.8 (35.1) | 1270.1 (20.1) | 0.429 | 0.397 |
*
p ≤0.050 (Sufficient vs. deficient 25(OH)D, Bonferroni-adjusted )
**
p ≤0.050 (Sufficient vs. insufficient 25(OH)D, Bonferroni-adjusted)
All models adjusted for age, BMI, season of blood draw, walk time, caffeine intake, alcohol, smoking, dietary calcium, supplementary calcium, health status, history of fracture, diabetes, myocardial infarction, and rheumatoid arthritis