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. 2011 Sep 7;31(36):12992–13001. doi: 10.1523/JNEUROSCI.2102-11.2011

Figure 6.

Figure 6.

Administration of GSH-lip does not affect phagocytosis of apoptotic neurons or O2·− accumulation in endothelial cells after neonatal stroke. A, B, At 24 h after reperfusion, a unilateral increase in expression of the scavenger receptors CD68 (A, ED1+ cells) and CD36 (B) occurs in both groups. GSH-lip induce further increase in CD36 expression (B, Western blot analysis, n = 4–5 per group). C, The number of cells with cleaved caspase-3 is similar in both groups, n = 5–6 per group. Black bars—medians. D, E, O2·− accumulates predominantly in the vessels within injured tissue, 10× objective (D). High O2·− is typically seen in both several cells within the same vessel (thin arrows) or in a single cell (arrowhead). E, Red, Ox-DHE; green, IB4; blue, DAPI. F, The number of Iba1+ cells that touch or engulf cells with cleaved caspase-3 is unchanged. n = 5–6 per group. G, H, The number of endothelial cells with high O2·− that interact with Iba1+ cells (G) or the number of endothelial cells with strong Ox-DHE (H) are not affected by GSH-lip treatment. n = 5–6 per group.