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. Author manuscript; available in PMC: 2013 Dec 13.
Published in final edited form as: J Med Chem. 2012 Nov 30;55(23):10551–10563. doi: 10.1021/jm301191p

Scheme 1.

Scheme 1

Synthesis of 3 and truncated analogs 5, 6 and 7a

a Reagents and conditions: (a) thiosemicarbazide, POCl3, 90 °C, 79%; (b) 2.0 equiv. phenylacetyl chloride, DMA, TEA 88%; (c) 1.0 equiv. phenylacetyl chloride, DMA, TEA, 11%; (d) H2O2, MeOH, 60%.