Table 1.
Clinical and histologic features of 16 patients with ENKTL
| Patient no. | Age | Sex | Primary sites | Ann Arbor stage | LDH level | B symptoms | IPI | Therapy | Response to treatment | LMP1 expression (IHS) | LMP2A expression (IHS) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |
36 |
M |
Nasal cavity |
II |
Normal |
Positive |
LI |
CHOP + FLAG |
PR |
6 |
6 |
| 2 |
36 |
M |
Oropharynx |
III |
High |
Positive |
HI |
CHOP |
PR |
4 |
2 |
| 3 |
57 |
M |
Nasal cavity |
II |
Normal |
Negative |
HI |
Surgery + CHOP |
CR |
2 |
1 |
| 4 |
55 |
M |
Larynx |
I |
Normal |
Positive |
LI |
Surgery + CHOP |
PR |
8 |
1 |
| 5 |
49 |
F |
Nasal cavity |
II |
High |
Negative |
L |
Surgery |
NR |
1 |
4 |
| 6 |
51 |
M |
Nasal cavity |
I |
High |
Negative |
LI |
CHOP + Radiotherapy |
PR |
2 |
1 |
| 7 |
67 |
M |
Nasal cavity |
II |
Normal |
Positive |
HI |
CHOP + GDP + CVAD |
CR |
9 |
4 |
| 8 |
25 |
M |
Oropharynx, palate |
II |
Normal |
Negative |
L |
CHOPE + ICE + Radiotherapy |
CR |
1 |
9 |
| 9 |
71 |
M |
Nasal cavity |
I |
High |
Positive |
LI |
CHOP + SMILE |
CR |
4 |
2 |
| 10 |
36 |
M |
Nasal cavity |
II |
Normal |
Negative |
L |
CHOP |
PR |
6 |
1 |
| 11 |
63 |
M |
Nasal cavity |
I |
Normal |
Negative |
L |
CEVP + Radiotherapy |
PR |
2 |
1 |
| 12 |
56 |
M |
Nasal cavity |
II |
Normal |
Positive |
LI |
Surgery + CHOP |
PR |
3 |
2 |
| 13 |
66 |
F |
Larynx |
II |
High |
Positive |
HI |
Surgery |
CR |
6 |
8 |
| 14 |
47 |
M |
Nasopharynx |
I |
Normal |
Negative |
L |
VEPA + Radiotherapy |
CR |
8 |
1 |
| 15 |
51 |
F |
Nasal cavity |
III |
Normal |
Positive |
HI |
DICE + SMILE |
PR |
9 |
9 |
| 16 | 27 | M | Nasal cavity | II | Normal | Negative | LI | Surgery + CHOP | CR | 3 | 6 |
LDH: lactate dehydrogenase; IPI: international prognostic index; IHS: immunohistochemistry score; LMP1: latent membrane protein 1; LMP2A: latent membrane protein 2A; L: low risk; LI: low-intermiediate risk; HI: high-intermiediate risk; CR: complete remission; PR: partial remission; NR: no response; CHOP: cyclophosphamide, hydroxydaunomycin, oncovin, prednisone; FLAG: fludarabine, arabinosylcytosine, granulocyte colony-stimulating factor; GDP: gemcitabine, dexamethasone, cisplatin; CVAD: cyclophosphamide, vindesine sulfate, adriamycin, cisplatin; CHOPE: cyclophosphamide, hydroxydaunomycin, oncovin, prednisone, etoposide; ICE: ifosfamide, cisplatin, etoposide; SMILE: steroid, methotrexate, ifosfamide, l-asparaginase, etoposide; CEVP: cyclophosphamide, epirubicin, vincristine, prednisone; VEPA: vincristine, cyclophosphamide, doxorubicin, predonisolone; DICE: dexamethasone, ifosfamide, cisplatin, etoposide.