Table 8.
Analysis of 5 highly-scored modules in each size category, with respect to functional groups and pathways, using MetaCoreTM from GeneGO
| Module | Functional groups | Pathway (p-value) |
|---|---|---|
|
Module Size: 3 |
|
|
| 1. CHK2:p53:E2F1 |
Apoptosis and Survival |
DNA-damage-induced apoptosis (1.63E-6) |
| 2. ATR:p53: E2F1 |
DNA Damage |
ATM/ATR regulation of G1/S checkpoint (5.7 E-8) |
| |
Apoptosis and Survival |
DNA-damage-induced apoptosis (1.63E-6) |
| 3. APEX1:HIF1A:p53 |
Transcription |
Role of AKT in hypoxia HIF1 activation (1.63E-9) |
| 4. IL-22:STAT3:STAT2 |
Immune Response |
IL-22 signalling pathway (4.51E-6) (Inflammation) |
| 5. IL-9R:STAT1:STAT3 |
Immune Response |
IL-9 signalling pathway (1.64E-5) |
|
Module Size: 4 |
|
|
| 1. COX-2:NF-kB:p53: NF-kB-p65 |
Immune Response |
MIF in innate immunity response (1.48E3) (Inflammation) |
| 2. TNFA: c-Jun: NF-kB:NF-kB-p65 |
Apoptosis and Survival |
TNFR1 signalling pathway (2.44E-14) |
| 3. p53:c-ABL:c-Jun: p73 |
Apoptosis and Survival |
p53 dependent apoptosis (7.67 E-9) |
| 4. ETS2:ETS1:c-Jun: c-Myc |
Immune Response |
ETV3 effect on CFSI promoted macrophage differentiation(1.04E-5) |
| 5. MAPK11:MEF2C: MEF2A:c-Jun |
Immune Response |
Function of MEF2 in T lymphocytes (0.0003) |
| |
|
TLR-signalling pathways (8.63E-10) (Inflammation) |
|
Module Size: 5 |
|
|
| 1. BCLX:DAND5:ESR1: c-Jun:SP1 |
Development |
Prolactin receptor signalling (3.52E-10) |
| |
DNA Damage |
Role of Brca1 and Brca2 in DNA repair (8E-13) |
| 2. TCF7L2:Lef1:c-Myc: PPARD:NRSF | Development | Wnt signalling pathway (2.45E-11) |