Table 1. Mutations impairing CAN neuron migration and axon outgrowth affect epidermal development.
| Genotype | Vulval Fatesa | n b | p-Valuec |
| Wild-type | 3.00 | 47 | |
| gap-1(lf) | 3.00 | 20 | |
| pry-1(lf) | 3.42d | 57 | |
| vab-8(gm99) | 3.19 | 21 | |
| vab-8(gm138) | 3.22 | 77 | |
| vab-8(ev411) | 3.00 | 68 | |
| ceh-10(lf) | 3.08 | 87 | |
| sfrp-1(lf) | 3.00 | 53 | |
| let-23(lf) | 0.52 | 24 | |
| let-23(lf); gap-1(lf) | 4.00 | 40 | <0.00001 versus let-23(lf) |
| pry-1(lf); let-23(lf) | 4.00 | 25 | <0.00001 versus let-23(lf) |
| let-23(lf); vab-8(gm99) | 1.85 | 24 | 0.0002 versus let-23(lf) |
| let-23(lf); vab-8(gm138) | 1.95 | 20 | 0.0001 versus let-23(lf) |
| let-23(lf); vab-8(ev411) | 0.66 | 40 | 0.54 versus let-23(lf) |
| let-23(lf); ceh-10(lf) | 0.64 | 21 | 0.65 versus let-23(lf) |
| let-23(lf); sfrp-1(lf) | 0.05 | 21 | |
| lin-3(lf) | 0.91 | 46 | |
| lin-3(lf); vab-8(gm99) | 2.09 | 20 | 0.002 versus lin-3(lf) |
| lin-3(lf); vab-8(gm138) | 2.12 | 46 | <0.00001 versus lin-3(lf) |
| lin-3(lf); vab-8(ev411) | 0.80 | 27 | 0.64 versus lin-3(lf) |
| ceh-10(lf); lin-3(lf) | 0.85 | 34 | 0.78 versus lin-3(lf) |
| let-60(dn)/+ e | 1.07 | 21 | |
| let-60(dn)/+; vab-8(gm99) e | 2.30 | 20 | 0.0005 versus let-60(dn) |
| let-60(dn)/+; vab-8(gm138) e | 2.48 | 20 | 0.00005 versus let-60(dn) |
a
Vulval fates: number of vulval progenitor cells adopting vulval fates.
b
n: number of animals assayed.
c
p-Values were calculated using a two-tailed Student's t test.
d
This number of vulval fates is an approximation, since in this background it is difficult to count the exact number of vulval cells descended from P9.p and P10.p.
e
The let-60 mutation was linked to unc-24(lf) and balanced by dpy-20(lf).
dn, dominant-negative; lf, loss-of-function.