Table 2.
PDB ID | Res. (Å) | Bisphosphonate inhibitora | Other ligands | Conformational state | Literature reference |
---|---|---|---|---|---|
2F7M |
2.30 |
- |
- |
Open |
[10] |
2F8C |
2.20 |
Zoledronate |
Pi |
Partially closed |
[10] |
2F8Z |
2.60 |
Zoledronate |
IPP |
Fully closed |
[10] |
1YV5 |
2.00 |
Risedronate |
Pi |
Partially closed |
[9] |
1ZW5 |
2.30 |
Zoledronate |
IPP |
Fully closed |
[9] |
3N45 |
1.88 |
Zoledronate |
Pi, FBS_04b |
Partially closed |
[21] |
3N46 |
2.35 |
Zoledronate |
Pi, NOV_980b |
Partially closed |
[21] |
4DEM |
1.85 |
YS0470 |
- |
Partially closed |
[12] |
4H5C |
2.02 |
YS0470 |
Pi |
Partially closed |
Current report |
4H5D |
2.02 |
YS0470 |
PPi |
Fully closed |
Current report |
4H5E | 2.05 | YS0470 | IPP | Fully closed | Current report |
aAll bisphosphonates are bound with Mg2+ ions.
bAllosteric inhibitors.
Please note that in the PDB structures 1YV5, 1ZW5, and 4DEM, the amino acids are numbered with an offset of 14 compared to the rest of the structures. The C-terminal tail KRRK residues in these structures are thus numbered from 364 to 367.