Table 2.
Main studies on the inhibition of skin wheal response in dogs - key findings
| Subjects | Intradermal challenge | Drug | Administration route | Treatment time | Wheal inhibition vs baseline | Ref |
|---|---|---|---|---|---|---|
| Healthy Beagle dogs |
Anti-canine IgE |
Corticosteroids (prednisolone) |
Oral |
Twice daily for 3 days |
No effect |
[38] |
| Dogs with pruritic dermatitis |
Histamine (5 different dilutions) |
Corticosteroids (hydrocortisone 1%) |
Topical (conditioner) |
Twice weekly for 6 weeks |
No effect |
[39] |
| Healthy Beagle dogs |
Histamine |
Corticosteroids (betamethasone) |
Topical (otic preparation) |
Twice daily for 2 weeks |
5.9% |
[40] |
| Healthy Beagle dogs |
D. farinae |
Corticosteroids (betamethasone) |
Topical (otic preparation) |
Twice daily for 2 weeks |
9% |
[40] |
| Healthy Beagle dogs |
Cynodon dactylon |
Corticosteroids (betamethasone) |
Topical (otic preparation) |
Twice daily for 2 weeks |
9.8% |
[40] |
| Healthy Beagle dogs |
Anti-canine IgE |
Corticosteroids (hydrocortisone 1%) |
Topical (conditioner) |
3 days |
14% (*) |
[41] |
| Healthy dogs |
Anti-canine IgE (different dilutions) |
Corticosteroids (triamcinolone) |
Topical (solution) |
7 days |
24-45% (§) depending on the stimulus concentration |
[42] |
| Healthy mixed breed dogs |
D. farinae |
Corticosteroids (prednisone) |
Oral |
7 days |
41% |
[43] |
| Atopic Maltese-beagle cross-breed dogs |
Anti-canine IgE |
Corticosteroids (hydrocortisone aceponate) |
Topical (spray) |
7 days |
72% |
[44] |
| Healthy mixed breed dogs |
D. farinae |
Antihistamines (cetrizine) |
Oral |
14 days |
49% |
[43] |
| Spontaneously Ascaris hypersensitive Beagle dogs |
A. suum |
Antihistamines (rupatadine) |
Oral |
Single pre-treatment dose |
35, 67 and 84% (#) |
[27] |
| Spontaneously Ascaris hypersensitive Beagle dogs |
A. suum |
Antihistamines (loratadine) |
Oral |
Single pre-treatment dose |
34, 61 and 66% (#) |
[27] |
| Healthy Beagle dogs |
PAF |
Antihistamines (rupatadine) |
Oral |
Single pre-treatment dose |
30% to 45% (¥) |
[47] |
| Healthy Beagle dogs |
Histamine |
Antihistamines (rupatadine) |
Oral |
Single pre-treatment dose |
50% to 80% (¥) |
[47] |
| Healthy Beagle dogs |
Histamine |
Antihistamines (cetrizine, loratadine, rupatadine, levocabastine) |
Oral |
Single pre-treatment dose |
70% to 80% (**) |
[48] |
| Healthy Beagle dogs | Histamine | Antihistamines (cetrizine, loratadine, rupatadine, levocabastine) | Oral | Single pre-treatment dose | 70% to 80% (**) | [48] |
(*) versus placebo group;
(§) versus vehicle-treated side;
(#) peak activity at 0.1, 1 and 10 mg/Kg respectively, 2 to 4 hrs after administration;
(¥) peak activity, 4 h after administration, depending on the dose;
(**) peak activity, 4 h after administration, depending on the compound and the dose.