Figure 7. Comparative gene expression profiling of AAV vector-induced inflammatory and immune response markers in the presence or absence UPR inhibitor during hepatic gene transfer in vivo.

Hepatic gene expression of various inflammatory cytokines in the scAAV2 injected BALB/c mice was measured 24 hours post vector administration. Genes which are significantly different between (2 fold, p<0.05) between mice that received AAV2 and metformin compared to the vector administered group alone, are shown.