Figure 2.

Event timelines for reinfection cases (A), intercalation cases (B), and an unclassified case (C) with multiple genotypes. A, Hepatitis C virus (HCV) viremia (IU/mL), alanine aminotransferase (ALT), genotype (GT), HCV RNA, and anti-HCV results showing acute HCV infection, reinfection, and reclearance among young injection drug users (IDUs) who have previously cleared HCV infection. Visit dates are shown in the lower boxes. Gray boxes show new acute HCV infections and black boxes show reinfections. Participants whose first infection serology was consistent with that of previously resolved infection (anti-HCV positive and HCV RNA negative) are shown in scored boxes. ^ in the GT box indicates that GT was determined by serotyping. B, HCV viremia (IU/mL), ALT, GT, HCV RNA, and anti-HCV results showing acute HCV infection and intercalation among young IDUs. Visit dates are shown in the lower boxes. Light gray boxes show new acute HCV infections and intercalations. Participants whose first infection serology was consistent with that of previously resolved infection (anti-HCV positive and HCV RNA. negative) are shown with scored boxes. ^ in the GT box indicates that GT was determined by serotyping. C, HCV viremia (IU/mL), ALT, GT, HCV RNA, and anti-HCV results in a young IDU whose infection could not be classified as either reinfection or intercalation. Results show acute HCV infection and either coinfection or superinfection. Visit dates are shown in the lower boxes. Lighter gray boxes show new acute HCV infection and darker gray box shows infection with a different genotype. Abbreviations: ALT, alanine aminotransferase; GT, genotype; HCV, hepatitis C virus; IL28B, interleukin 28B.