Table 3. HLA allele frequencies in Ro(+)La(+) RA patients.
| Ro(+)La(+) | Ro(−)La(−) | P | OR | Pc | 95%CI | |
| DRB1*01∶01 | 3 (3.8) | 110 (7.8) | 0.2739 | 0.46 | NS | |
| DRB1*03∶01 | 1 (1.3) | 0 (0.0) | 0.0538 | 53.15 | NS | |
| DRB1*04∶01 | 0 (0.0) | 52 (3.7) | 0.1097 | 0.16 | NS | |
| DRB1*04∶03 | 0 (0.0) | 20 (1.4) | 0.6214 | 0.42 | NS | |
| DRB1*04∶04 | 0 (0.0) | 3 (0.2) | 1.0000 | 2.49 | NS | |
| DRB1*04∶05 | 15 (18.8) | 406 (28.8) | 0.0555 | 0.57 | NS | |
| DRB1*04∶06 | 1 (1.3) | 25 (1.8) | 1.0000 | 0.70 | NS | |
| DRB1*04∶07 | 0 (0.0) | 3 (0.2) | 1.0000 | 2.49 | NS | |
| DRB1*04∶10 | 5 (6.3) | 33 (2.3) | 0.0492 | 2.78 | NS | (1.05–7.32) |
| DRB1*07∶01 | 1 (1.3) | 6 (0.4) | 0.3213 | 2.96 | NS | |
| DRB1*08∶02 | 4 (5.0) | 21 (1.5) | 0.0414 | 3.48 | NS | (1.16–10.38) |
| DRB1*08∶03 | 5 (6.3) | 52 (3.7) | 0.2280 | 1.74 | NS | |
| DRB1*09∶01 | 6 (7.5) | 243 (17.3) | 0.0205 | 0.39 | 0.5728 | (0.17–0.90) |
| DRB1*10∶01 | 0 (0.0) | 12 (0.9) | 1.0000 | 0.69 | NS | |
| DRB1*11∶01 | 1 (1.3) | 17 (1.2) | 1.0000 | 1.04 | NS | |
| DRB1*12∶01 | 4 (5.0) | 39 (2.8) | 0.2865 | 1.85 | NS | |
| DRB1*12∶02 | 3 (3.8) | 20 (1.4) | 0.1223 | 2.70 | NS | |
| DRB1*13∶01 | 0 (0.0) | 3 (0.2) | 1.0000 | 2.49 | NS | |
| DRB1*13∶02 | 4 (5.0) | 60 (4.3) | 0.7735 | 1.18 | NS | |
| DRB1*14∶02 | 0 (0.0) | 2 (0.1) | 1.0000 | 3.49 | NS | |
| DRB1*14∶03 | 1 (1.3) | 10 (0.7) | 0.4566 | 1.77 | NS | |
| DRB1*14∶05 | 2 (2.5) | 14 (1.0) | 0.2111 | 2.55 | NS | |
| DRB1*14∶06 | 3 (3.8) | 15 (1.1) | 0.0681 | 3.62 | NS | |
| DRB1*14∶07 | 0 (0.0) | 1 (0.1) | 1.0000 | 5.83 | NS | |
| DRB1*14∶54 | 2 (2.5) | 34 (2.4) | 1.0000 | 1.04 | NS | |
| DRB1*15∶01 | 12 (15.0) | 75 (5.3) | 0.0017 | 3.14 | 0.0470 | (1.63–6.05) |
| DRB1*15∶02 | 7 (8.8) | 124 (8.8) | 1.0000 | 0.99 | NS | |
| DRB1*16∶02 | 0 (0.0) | 8 (0.6) | 1.0000 | 1.02 | NS | |
| DQB1*02∶01 | 2 (2.5) | 6 (0.4) | 0.0647 | 5.99 | 0.9710 | |
| DQB1*03∶01 | 12 (15.0) | 133 (9.4) | 0.1183 | 1.69 | NS | |
| DQB1*03∶02 | 4 (5.0) | 73 (5.2) | 1.0000 | 0.96 | NS | |
| DQB1*03∶03 | 6 (7.5) | 229 (16.3) | 0.0392 | 0.42 | 0.5886 | (0.18–0.97) |
| DQB1*03∶06 | 0 (0.0) | 3 (0.2) | 1.0000 | 2.49 | NS | |
| DQB1*04∶01 | 15 (18.8) | 432 (30.7) | 0.0238 | 0.52 | 0.3573 | (0.29–0.92) |
| DQB1*04∶02 | 6 (7.5) | 35 (2.5) | 0.0198 | 3.18 | 0.2974 | (1.30–7.80) |
| DQB1*05∶01 | 3 (3.8) | 125 (8.9) | 0.1484 | 0.40 | NS | |
| DQB1*05∶02 | 1 (1.3) | 27 (1.9) | 1.0000 | 0.65 | NS | |
| DQB1*05∶03 | 3 (3.8) | 29 (2.1) | 0.2450 | 1.85 | NS | |
| DQB1*06∶01 | 12 (15.0) | 179 (12.7) | 0.4962 | 1.21 | NS | |
| DQB1*06∶02 | 12 (15.0) | 75 (5.3) | 0.0017 | 3.14 | 0.0252 | (1.63–6.05) |
| DQB1*06∶03 | 0 (0.0) | 3 (0.2) | 1.0000 | 2.49 | NS | |
| DQB1*06∶04 | 4 (5.0) | 57 (4.0) | 0.5656 | 1.25 | NS | |
| DQB1*06∶09 | 0 (0.0) | 1 (0.1) | 1.0000 | 5.83 | NS | |
| DPB1*02∶01 | 11 (13.8) | 387 (27.5) | 0.0061 | 0.42 | 0.0913 | (0.22–0.80) |
| DPB1*02∶02 | 1 (1.3) | 59 (4.2) | 0.3713 | 0.29 | NS | |
| DPB1*03∶01 | 5 (6.3) | 56 (4.0) | 0.3746 | 1.61 | NS | |
| DPB1*04∶01 | 2 (2.5) | 55 (3.9) | 0.7656 | 0.63 | NS | |
| DPB1*04∶02 | 4 (5.0) | 171 (12.1) | 0.0506 | 0.38 | 0.7591 | |
| DPB1*05∶01 | 44 (55.0) | 493 (35.0) | 0.0005 | 2.27 | 0.0069 | (1.44–3.57) |
| DPB1*06∶01 | 0 (0.0) | 9 (0.6) | 1.0000 | 0.92 | NS | |
| DPB1*09∶01 | 6 (7.5) | 112 (8.0) | 1.0000 | 0.94 | NS | |
| DPB1*13∶01 | 2 (2.5) | 16 (1.1) | 0.2517 | 2.23 | NS | |
| DPB1*14∶01 | 4 (5.0) | 25 (1.8) | 0.0660 | 2.91 | 0.9907 | |
| DPB1*17∶01 | 0 (0.0) | 5 (0.4) | 1.0000 | 1.58 | NS | |
| DPB1*19∶01 | 0 (0.0) | 5 (0.4) | 1.0000 | 1.58 | NS | |
| DPB1*38∶01 | 0 (0.0) | 3 (0.2) | 1.0000 | 2.49 | NS | |
| DPB1*41∶01 | 0 (0.0) | 7 (0.5) | 1.0000 | 1.16 | NS | |
| DPB1*47∶01 | 1 (1.3) | 3 (0.2) | 0.1985 | 5.93 | NS |
RA: rheumatoid arthritis, Ro(+)La(+)RA: anti-Ro/SS-A- and anti-La/SS-B-positive RA, Ro(−)La(−)RA: anti-Ro/SS-A- and anti-La/SS-B-negative RA. OR: odds ratio, CI: confidence interval, Pc: corrected P value, NS: not significant. Allele frequencies are shown in parenthesis (%). Associations were established by Fisher’s exact test using 2×2 contingency tables.