Table 1.
Patient | Age at HCT (months) | Gender | Mutation | Inheritance | Pretransplant Infections*** |
---|---|---|---|---|---|
1 | 8 | F | unknown | AR | Colitis, bronchiolitis, thrush |
2 | 25 | M | unknown | AR | Diffuse candida peritonitis, thrush |
3 | 56 | M | gp91phox | x-linked | Multiple pneumonias, apthous ulcers |
4 | 17 | M | unknown | AR | Burkholderia pneumonia |
5 | 122 | M | gp91phox | x-linked | Pneumonias, lung aspergilloma, multiple osteomyelitis, salmonella gastroenteritis |
6 | 109 | M | p22phox | AR | Serratia osteomyelitis, mycobacterium skin nodules, resistant lung acid fast bacilli, bladder granulomas |
7 | 18 | M | gp91phox | x-linked | Staphylococcal skin infection, lymphadenitis, pulmonary nodules |
8 | 100 | M | gp91phox | x-linked | Kidney granulomas, pneumonia, colitis |
9 | 140 | M | gp91phox | x-linked | Nocardia pneumonia, gut mucormycosis, sinusitis, colitis |
10 | 73 | M | gp91phox | x-linked | Klebsiella abscess, pulmonary nodules, multiple pneumonias, gingivitis, colitis |
11 | 14 | M | gp91phox | x-linked | MRSA liver abscess, Staphylococcus aureus Neck abscess, mediastinal cyst |
12 | 46 | M | gp91phox | x-linked | Serratia Abscess, apthous ulcers |
Patients had a median of 3 serious infections by the time they underwent stem cell transplantation.