Table 4.
Summary of Current Series and Published Data on Bone Marrow Transplants for CGD.
Source | Center or Group | Donor Source (# of patients) | Conditioning | Median Follow-up (months) | OS% | Engraftment % | Patients achieving high (>90%) donor chimerism |
---|---|---|---|---|---|---|---|
Tewari, 2012 | Duke University Medical Center | R-M-BM (5) | MAC | 97 | 100 | 100 | 100 |
Gozdzik, 2011 | Univeristy Children’s Hospital, Cracow | R-M-BM (2), U-M-BM (3), U-MM-BM(1) | MAC (5), RIC (1) | Mean: 20 | 100 | 100 | 100 |
Soncini, 2009 | UK Northern Supra Regional HSCT Unit | R-M-BM (9), U-M-BM (6), U-M-PBSC (2), U-MM-PBSC (1) | MAC(14), RIC(4) | 61 | 88 MAC(100), RIC (50) | MAC: 100 RIC: 75 |
NA |
Schuetz, 2009 | Universtiy Hospital Ulm | R-M-BM (3), U-M-BM (6), U-M-PBSC(3) | MAC (9), RIC (3) | 53 | 75 MAC(57), RIC (100) | MAC: 100 RIC: 66 |
92 |
Güngör, 2005 | University Children’s Hospital of Zurich | M-U-BM(1), M-R-BM(2) | RIC | 17 | 100 | 100 | 100 |
Seger, 2002 | EBMT | R-M-BM(25), U-M-BM (2) | MAC(23), RIC (4) | 24 | 85 MAC(92), RIC (75) | MAC: 95 RIC: 50 |
85 |
Horwitz, 2001 | National Institutes of Health, Bethesda | R-M-BM(10) | RIC | 17 | 70 | 80 | 60 |
R-M-BM: Related matched bone marrow, U-M-BM: Unrelated matched bone marrow; U MM-BM: Unrelated mismatched bone marrow; U-M-PBSC: Unrelated matched peripheral blood stem cells; U-MM-PBSC: Unrelated mismatched peripheral blood stem cells. MAC: Myeloablative conditioning.